Preoperative peripheral naïve / memory ratio and prognosis of nonsmall-cell lung cancer patients

• Published in: Annals of thoracic and cardiovascular surgery Vol. 13; no. 6; pp. 384 - 390
• Main Authors: Hara, Masaki, Matsuzaki, Yasunori, Shimizu, Tetsuya, Tomita, Masaki, Ayabe, Takanori, Enomoto, Yusuke, Onitsuka, Toshio
• Format: Journal Article
• Language: English
• Published: Japan 01.12.2007
• Subjects: Aged; Carcinoma, Non-Small-Cell Lung - immunology; Carcinoma, Non-Small-Cell Lung - mortality; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Female; Humans; Immunologic Memory; Leukocyte Common Antigens - immunology; Lung Neoplasms - immunology; Lung Neoplasms - mortality; Male; Middle Aged; Prognosis; Survival Analysis
• ISSN: 1341-1098; 2186-1005

This study focused on the relationship between preoperative peripheral blood CD4(+) naïve/memory ratio and prognosis following surgery for patients with nonsmall-cell lung cancer. After measuring CD3, CD4, CD8, CD45RA, CD45RO, CD25, and intracellular CTLA4 levels, CD4(+) naïve/memory ratios were determined for 13 controls and 38 patients. Although we observed no significant difference in the ratios, the patients exhibited a wider range of values than the controls. Of the 38 patients, 24 subsequently underwent surgery and were divided into three groups based on their preoperative CD4(+) naïve/memory ratio: Group I: <0.3; Group II: 0.3-0.8; and Group III: >0.8. Survival times were then evaluated. Group II survival was significantly better than Groups I and III. Our data suggest that the preoperative CD4(+) naïve/memory ratio may serve as a prognostic factor for nonsmall-cell lung cancer patients.