Lack of association between smoking and CYP2A6 gene polymorphisms in A Japanese population

This study determined the genotypes of the CYP2A6 gene in 96 smokers and 141 non-smokers in a Japanese population. The frequencies of wild-type of the CYP2A6* 1 and those with a whole deletion of the CYP2A6 gene were 93 (96.9%) and 3 (3.1%) in 96 smokers, and 134 (95.0%) and 7 (5.0%) in non-smokers,...

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Published inNihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence Vol. 36; no. 5; p. 486
Main Authors Zhang, X, Amemo, K, Ameno, S, Iwahashi, K, Kinoshita, H, Kubota, T, Mostofa, J, Ijiri, I
Format Journal Article
LanguageEnglish
Published Japan 01.10.2001
Subjects
Adult
Aryl Hydrocarbon Hydroxylases
Asian Continental Ancestry Group
Cytochrome P-450 CYP2A6
Cytochrome P-450 Enzyme System - genetics
Female
Gene Frequency
Genotype
Humans
Japan
Male
Middle Aged
Mixed Function Oxygenases - genetics
Polymorphism, Genetic
Smoking - genetics
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Summary:This study determined the genotypes of the CYP2A6 gene in 96 smokers and 141 non-smokers in a Japanese population. The frequencies of wild-type of the CYP2A6* 1 and those with a whole deletion of the CYP2A6 gene were 93 (96.9%) and 3 (3.1%) in 96 smokers, and 134 (95.0%) and 7 (5.0%) in non-smokers, respectively. In addition, neither the CYP2A6* 2 nor CYP2A6* 3 alleles were observed in the population studied. There were no significant differences in the CYP2A6 genotype frequencies between smokers and non-smokers, as well as in the number of cigarettes smoked and the nicotine amounts inhaled per day between the CYP2A6* 1 and the deletion of CYP2A6. These results suggest that either the deletion or non-deletion of the CYP2A6 gene shows no significant effect on smoking behavior for the Japanese population examined.
ISSN:1341-8963