CLINICAL EVALUATION OF ME 127 IN THE FIELD OF UROLOGY

Eighty patients with urological infections were treated with the novel oral cephem antibiotic, ME127, in doses of 2 to 6 mg/day, and the following results were obtained. The drug was effective in 1% of the 15 patients with acute uncomplicated cystitis and in 69.4% of the 36 patients with chronic com...

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Published inCHEMOTHERAPY Vol. 40; no. Supplement2; pp. 488 - 497
Main Authors Suzuki, Keizo, Horiba, Masaki, Naide, Yorio, Hibi, Hideo, Asano, Haruyoshi, Ishikawa, Kiyohito, Okishio, Norihiko
Format Journal Article
LanguageEnglish
Japanese
Published Japanese Society of Chemotherapy 1992
Subjects
Concentration of prostatic fluid
Genital infection
ME 1207
Serratia
UTI
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Summary:Eighty patients with urological infections were treated with the novel oral cephem antibiotic, ME127, in doses of 2 to 6 mg/day, and the following results were obtained. The drug was effective in 1% of the 15 patients with acute uncomplicated cystitis and in 69.4% of the 36 patients with chronic complicated urinary tract infection according to the criteria proposed by the Japanese UTI Committee, and in 8 out of 9 male patients with urethritis and in the 1 patient with chronic prostatitis. As to side effects of the drug, two patients had loose stools and 1 had diarrhea. Regarding laboratory finding, 7 patients elevated GOT and GPT, but these values normalized within a week after completion of therapy.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.40.Supplement2_488