Pharmacokinetics of ritipenem acoxil
Ritipenem acoxil (RIPM-AC) is a new oral penem antibiotic. We investigated the pharmacokinetics of RIPM-AC and cefotiam hexetil (CTM-HE) by the cross-over method. The pharmacokinetics of RIPM-AC and CTM-HE, each orally administrated at a dose of 200 mg, were compared in healthy male volunteers. The...
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| Published in | Japanese Journal of Chemotherapy Vol. 43; no. Supplement3; pp. 286 - 291 |
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| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of Chemotherapy
1995
公益社団法人 日本化学療法学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1340-7007 1884-5886 |
| DOI | 10.11250/chemotherapy1995.43.Supplement3_286 |
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| Abstract | Ritipenem acoxil (RIPM-AC) is a new oral penem antibiotic. We investigated the pharmacokinetics of RIPM-AC and cefotiam hexetil (CTM-HE) by the cross-over method. The pharmacokinetics of RIPM-AC and CTM-HE, each orally administrated at a dose of 200 mg, were compared in healthy male volunteers. The Cmax values of ritipenem (RIPM) and cefotiam (CTM) were 2.09μgg/ml and 2.85μg/ml, respectively. The T1/2 of RIPM and CTM were 0.56 h and 0.71 h, and the AUC0-12 values were 2.10 μg·h/ml and 4.99 μg·h/ml. The mean urinary recovery rates of RIPM and CTM up to 12 h after a single oral administration were 11.3% and 38.9%. |
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| AbstractList | Ritipenem acoxil (RIPM-AC) is a new oral penem antibiotic. We investigated the pharmacokinetics of RIPM-AC and cefotiam hexetil (CTM-HE) by the cross-over method.The pharmacokinetics of RIPM-AC and CTM-HE, each orally administrated at a dose of 200 mg, were compared in healthy male volunteers. The Cmax values of ritipenem (RIPM) and cefotiam (CTM) were 2.09μgg/ml and 2.85μg/ml, respectively. The T1/2 of RIPM and CTM were 0.56 h and 0.71 h, and the AUC0-12 values were 2.10 μg·h/ml and 4.99 μg·h/ml. The mean urinary recovery rates of RIPM and CTM up to 12 h after a single oral administration were 11.3% and 38.9%.
健常成人男子ボランティアを対象として, 新規経口ペネム系抗生物質であるritipenem acoxil (RIPM-AC) の体内動態について検討した。なお, クロスオーバー法でcefotiam hexetil (CTMHE) の体内動態についても検討した。健常成人男子ボランティアにRIPM-AC, CTM-HEともに200mg錠を単回投与し, クロスオーバー法で各薬剤の血漿中濃度, および尿中排浬を検討した。最高血漿中濃度 (Cmax) は, ritipenem (RIPM) では2.09μg/ml, cefotiam (CTM) では2.85μg/mlを示した。また, RIPM, CTMの血漿中濃度半減期 (T1/2) は, それぞれ0.56h, 0.71h, 12時間までの血漿中濃度曲線下面積 (AUC0-12) はそれぞれ2.10μg・h/ml, 4.99μg・h/mlであった。浩性体の累積尿中排泄率は12時間までで, RIPM 11.3%, CTM38.9%であった。 Ritipenem acoxil (RIPM-AC) is a new oral penem antibiotic. We investigated the pharmacokinetics of RIPM-AC and cefotiam hexetil (CTM-HE) by the cross-over method. The pharmacokinetics of RIPM-AC and CTM-HE, each orally administrated at a dose of 200 mg, were compared in healthy male volunteers. The Cmax values of ritipenem (RIPM) and cefotiam (CTM) were 2.09μgg/ml and 2.85μg/ml, respectively. The T1/2 of RIPM and CTM were 0.56 h and 0.71 h, and the AUC0-12 values were 2.10 μg·h/ml and 4.99 μg·h/ml. The mean urinary recovery rates of RIPM and CTM up to 12 h after a single oral administration were 11.3% and 38.9%. |
| Author | Sakuramoto, Koushi Uno, Satoshi Ohmori, Hiroyuki Irie, Shin Takenaka, Tadasu Fujita, Ryuji Nasu, Yoshitsugu Watanabe, Toyohiko Kaneshige, Tetsuzo Hata, Kazuhiro Hayashi, Toshihide Kumon, Hiromi Tsugawa, Masaya Ono, Noriaki Monden, Kouichi |
| Author_FL | 門田 晃一 小野 憲昭 畠 和宏 入江 伸 宇埜 智 櫻本 耕司 渡辺 豊彦 藤田 竜二 那須 良次 竹中 皇 津川 昌也 金重 哲三 公文 裕巳 大森 弘之 林 俊秀 |
| Author_FL_xml | – sequence: 1 fullname: 小野 憲昭 – sequence: 2 fullname: 藤田 竜二 – sequence: 3 fullname: 渡辺 豊彦 – sequence: 4 fullname: 竹中 皇 – sequence: 5 fullname: 門田 晃一 – sequence: 6 fullname: 宇埜 智 – sequence: 7 fullname: 櫻本 耕司 – sequence: 8 fullname: 林 俊秀 – sequence: 9 fullname: 畠 和宏 – sequence: 10 fullname: 那須 良次 – sequence: 11 fullname: 津川 昌也 – sequence: 12 fullname: 公文 裕巳 – sequence: 13 fullname: 大森 弘之 – sequence: 14 fullname: 入江 伸 – sequence: 15 fullname: 金重 哲三 |
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| DocumentTitleAlternate | Ritipenem acoxilの体内動態の検討 Cefotiam hexetilとの比較 |
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| References | 4) 武田勝男, 矢野茂, 平野直光, 松下忠弘, 大橋元明, 山口東太郎: Ritipenem acoxilのbioassay法による体液内濃度測定法. 日本化学療法学会雑誌43 (S-3): 97-102, 1995 2) Neu H C, Chin N X, Labthavikul P: The in vitro activity of a novel penem FCE22101 compared to other β-lactam antibiotics. J Antimicrob Chemother 16: 305-313, 1985 3) 熊澤淨一: 第42回日本化学療法学会総会, 新薬シンポジウム, FC/TA-891, 福岡, 1994 5) 畚野剛, 他: 生体試料中のcefotiam hexetil関連化合物の微生物学的定量法. Chemotherapy 36: 111-115, 1988 1) Wise R, Andrews J M, Danks G: Comparison of in vitro activity of FCE 22101, & new penem, with those of other β-Lactam antibiotics. Antimicrob Agent and Chemother 12: 909-914, 1983 |
| References_xml | – reference: 2) Neu H C, Chin N X, Labthavikul P: The in vitro activity of a novel penem FCE22101 compared to other β-lactam antibiotics. J Antimicrob Chemother 16: 305-313, 1985 – reference: 1) Wise R, Andrews J M, Danks G: Comparison of in vitro activity of FCE 22101, & new penem, with those of other β-Lactam antibiotics. Antimicrob Agent and Chemother 12: 909-914, 1983 – reference: 3) 熊澤淨一: 第42回日本化学療法学会総会, 新薬シンポジウム, FC/TA-891, 福岡, 1994 – reference: 4) 武田勝男, 矢野茂, 平野直光, 松下忠弘, 大橋元明, 山口東太郎: Ritipenem acoxilのbioassay法による体液内濃度測定法. 日本化学療法学会雑誌43 (S-3): 97-102, 1995 – reference: 5) 畚野剛, 他: 生体試料中のcefotiam hexetil関連化合物の微生物学的定量法. Chemotherapy 36: 111-115, 1988 |
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| Title | Pharmacokinetics of ritipenem acoxil |
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