Pharmacokinetics of ritipenem acoxil

• Published in: Japanese Journal of Chemotherapy Vol. 43; no. Supplement3; pp. 286 - 291
• Main Authors: Ohmori, Hiroyuki, Tsugawa, Masaya, Ono, Noriaki, Sakuramoto, Koushi, Kumon, Hiromi, Monden, Kouichi, Hata, Kazuhiro, Irie, Shin, Watanabe, Toyohiko, Nasu, Yoshitsugu, Takenaka, Tadasu, Uno, Satoshi, Kaneshige, Tetsuzo, Hayashi, Toshihide, Fujita, Ryuji
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1995; 公益社団法人 日本化学療法学会
• Subjects: cefoiam hexetil; ritipenem acoxil; クロスオーバー; 体内動態
• ISSN: 1340-7007; 1884-5886
• DOI: 10.11250/chemotherapy1995.43.Supplement3_286

Ritipenem acoxil (RIPM-AC) is a new oral penem antibiotic. We investigated the pharmacokinetics of RIPM-AC and cefotiam hexetil (CTM-HE) by the cross-over method. The pharmacokinetics of RIPM-AC and CTM-HE, each orally administrated at a dose of 200 mg, were compared in healthy male volunteers. The Cmax values of ritipenem (RIPM) and cefotiam (CTM) were 2.09μgg/ml and 2.85μg/ml, respectively. The T1/2 of RIPM and CTM were 0.56 h and 0.71 h, and the AUC0-12 values were 2.10 μg·h/ml and 4.99 μg·h/ml. The mean urinary recovery rates of RIPM and CTM up to 12 h after a single oral administration were 11.3% and 38.9%.