BACTERIOLOGICAL, PHARMACOKINETIC AND CLINICAL STUDIES ON ME 1207 IN OTORHINOLARYNGOLOGICAL INFECTION

• Published in: CHEMOTHERAPY Vol. 40; no. Supplement2; pp. 636 - 642
• Main Authors: Miyamoto, Naoya, Kobayashi, Takehiro, Yamamoto, Shinichiro, Baba, Shunkichi, Ito, Haruo, Tonai, Akira, Isaji, Hiroko, Shimada, Junichiro, Nagata, Soichiro
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1992
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.40.Supplement2_636

Bacteriological, pharmacokinetic and clinical studies were carried out with ME 1207 in otorhinolaryngological infection. The results were as follows. 1. The antibacterial activity of ME 1206 against Staphylococcus aureus (15 strains) was superior to that of cefaclor and cefixime, and against Pseudomonas aeruginosa (14 strains) was excellent compared to the other two drug. 2. The concentration of ME 1206 was 0.08μg/g in the tonsils, 0.16μg/g in the mucous membrane of the maxillary sinus and 0.2μg/g in the mucous membrane of the ethmoidal sinus. 3. The overall clinical efficacy of ME 1207 was 70.8%. There were no abnormal laboratory findings and eruption was observed in one case.