Spectrophotometric determination of chlorpheniramine with Plasmocorinth B

A number of spectrophotometric methods have been given for the determination of chlorpheniramine, an antihistaminate, but there have been no specific reagents. Plasmocorinth B as a metal reagent reacts with chlorpheniramine in an acidic medium to form a stable complex extractable into chloroform. Th...

Full description

Saved in:
Bibliographic Details
Published inBUNSEKI KAGAKU Vol. 17; no. 7; pp. 843 - 846
Main Authors OHASHI, Kaoru, MATSUO, Masaaki, KAWASAKI, Atsuko, KOIKE, Hisashi
Format Journal Article
LanguageJapanese
Published The Japan Society for Analytical Chemistry 05.07.1968
Online AccessGet full text

Cover

More Information
Summary:A number of spectrophotometric methods have been given for the determination of chlorpheniramine, an antihistaminate, but there have been no specific reagents. Plasmocorinth B as a metal reagent reacts with chlorpheniramine in an acidic medium to form a stable complex extractable into chloroform. The extract shows an absorption maximum at 567 mμ, and a linear relation holds between the absorbance and the chlorpheniramine concentration over 0.50.3 mg/ml. The reagent has been therefore applied to the determination. There are only few interfering substances, and the procedure is comparatively simple and seems practically useful.
ISSN:0525-1931
DOI:10.2116/bunsekikagaku.17.843