RE-EVALUATION OF THERAPEUTIC DRUGS FOR CHRONIC BACTERIAL PROSTATITIS REPORT 1: THE pH EFFECT ON THE ANTIBACTERIAL ACTIVITY

Antibacterial activities of sulfamethoxazole-trimethoprim (ST), minocycline (MINO), doxycycline (DOXY), erythromycin (EM), 9-3''-diacetyl-midecamycin (MOM), cefaclor (CCL), T-2525, enoxacin (ENX), and ciprofloxacin (CPFX) against E. coli, K. pneumonias, P. mirabilis and E. faecalis were st...

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Published inCHEMOTHERAPY Vol. 35; no. 11; pp. 824 - 832
Main Authors MURANAKA, KOJI, SUZUKI, YUJI, NAKAMURA, NAOHIRO, GOUBARA, MASARU, KOMEDA, HISAO, OKANO, MANABU, AKINO, HIRONOBU, ISOMATSU, YUKISHIGE, KANIMOTO, YUSUKE, SHIMIZU, YASUO, KAWADA, YUKIMICHI
Format Journal Article
LanguageJapanese
Published Japanese Society of Chemotherapy 1987
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Summary:Antibacterial activities of sulfamethoxazole-trimethoprim (ST), minocycline (MINO), doxycycline (DOXY), erythromycin (EM), 9-3''-diacetyl-midecamycin (MOM), cefaclor (CCL), T-2525, enoxacin (ENX), and ciprofloxacin (CPFX) against E. coli, K. pneumonias, P. mirabilis and E. faecalis were studied under a variety of pH conditions. Whereas the antibacterial activity of EM was markedly enhanced with alkalinisation, those of MINO and DOXY were decreased. Those of the other drugs were unchanged or slightly decreased with snap linization. Since prostatic fluid in human chronic bacterial prostatitis is alkaline, we suggest that the clinical value of EM (whose antibacterial activity is enhanced with alkalinization), ENX and CPFX in this condition should be investigated.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.35.824