A case of cirrhosis with hepatitis C virus infection developing hepatocellular carcinoma 20 years after achieving sustained virological response to interferon therapy

An 86-year-old male was diagnosed with liver cirrhosis and hepatitis C virus (HCV) infection, and he was treated with interferon (IFN) therapy 20 years ago. He achieved a sustained virological response (SVR) and was followed up with blood tests and ultrasonography twice a year. Twenty years later, a...

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Published inKanzo Vol. 57; no. 1; pp. 27 - 33
Main Authors Okabe, Junya, Fukuda, Kazuto, Iwamoto, Takayuki, Yamagata, Yosuke, Tani, Mizuki, Yasuoka, Hidetaka, Yagi, Mai, Onishi, Atsunori, Kogita, Sachiyo, Sawai, Yoshiyuki, Igura, Takumi, Yamaguchi, Noritaka, Matsumoto, Yasushi, Nakahara, Masanori, Ohashi, Hiroshi, Marukawa, Taro, Maeda, Yuichi, Shinomura, Yasuhisa, Imai, Yasuharu
Format Journal Article
LanguageJapanese
Published The Japan Society of Hepatology 01.02.2016
Subjects
hepatocellular carcinoma
interferon
long time
sustained virological response
type C hepatic cirrhosis
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Abstract An 86-year-old male was diagnosed with liver cirrhosis and hepatitis C virus (HCV) infection, and he was treated with interferon (IFN) therapy 20 years ago. He achieved a sustained virological response (SVR) and was followed up with blood tests and ultrasonography twice a year. Twenty years later, a high-echoic nodule with 15 mm diameter was detected by ultrasonography and diagnosed as a hepatocellular carcinoma by magnetic resonance imaging and hepatic angiography. The patient was treated with transcatheter arterial chemoembolization followed by radiofrequency ablation. Long-term follow-up may be needed for patients with HCV even after the achievement of SVR to IFN therapy.
AbstractList An 86-year-old male was diagnosed with liver cirrhosis and hepatitis C virus (HCV) infection, and he was treated with interferon (IFN) therapy 20 years ago. He achieved a sustained virological response (SVR) and was followed up with blood tests and ultrasonography twice a year. Twenty years later, a high-echoic nodule with 15 mm diameter was detected by ultrasonography and diagnosed as a hepatocellular carcinoma by magnetic resonance imaging and hepatic angiography. The patient was treated with transcatheter arterial chemoembolization followed by radiofrequency ablation. Long-term follow-up may be needed for patients with HCV even after the achievement of SVR to IFN therapy.
Author Tani, Mizuki
Matsumoto, Yasushi
Nakahara, Masanori
Fukuda, Kazuto
Yasuoka, Hidetaka
Sawai, Yoshiyuki
Ohashi, Hiroshi
Onishi, Atsunori
Yamaguchi, Noritaka
Yagi, Mai
Imai, Yasuharu
Marukawa, Taro
Okabe, Junya
Maeda, Yuichi
Kogita, Sachiyo
Igura, Takumi
Yamagata, Yosuke
Iwamoto, Takayuki
Shinomura, Yasuhisa
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  fullname: Fukuda, Kazuto
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  fullname: Yamagata, Yosuke
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  fullname: Yasuoka, Hidetaka
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  fullname: Yagi, Mai
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  fullname: Igura, Takumi
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  fullname: Yamaguchi, Noritaka
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  fullname: Matsumoto, Yasushi
  organization: Department of Gastroenterology, Ikeda Municipal Hospital
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  fullname: Nakahara, Masanori
  organization: Department of Gastroenterology, Ikeda Municipal Hospital
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  fullname: Ohashi, Hiroshi
  organization: Department of Pathology, Ikeda Municipal Hospital
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  fullname: Marukawa, Taro
  organization: Department of Radiology, Ikeda Municipal Hospital
– sequence: 17
  fullname: Maeda, Yuichi
  organization: Maeda clinic
– sequence: 18
  fullname: Shinomura, Yasuhisa
  organization: Department of Gastroenterology, Ikeda Municipal Hospital
– sequence: 19
  fullname: Imai, Yasuharu
  organization: Department of Gastroenterology, Ikeda Municipal Hospital
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interferon
long time
sustained virological response
type C hepatic cirrhosis
Title A case of cirrhosis with hepatitis C virus infection developing hepatocellular carcinoma 20 years after achieving sustained virological response to interferon therapy
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