Biological and Bacteriostatic Action of New Furan-derivative, “Panfuran”

• Published in: Journal of the Japanese Association for Infectious Diseases Vol. 36; no. 4; pp. 129 - 135
• Main Authors: KAIBARA, Morio, TANAKA, Atsuko
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Association for Infectious Diseases 1962
• ISSN: 0021-4817; 1884-5681
• DOI: 10.11552/kansenshogakuzasshi1926.36.129

The antibacterial activity of nitrofuran-derivatives has attracted the attention of many workers. As the nitrofuran-derivatives newly synthesized nitrofuran-derivatives combining with 1.2.4. triazine nucleus, Panfuran-acetate and Panfuran-100, 2 were used. This paper is a report of fundamental studies on Panfuran-derivatives and the sensitivity test against dysentery bacilli and Staphylococci isolated from the clinical cases in Toritsu-Komagome Hospital. The LD50 of the derivatives to mice is 4, 495 mg/kg by oral administration in the case of Panfuran-acetate and 2, 690 mg/ kg by intraperitoneal administration. The results show that the derivatives have only a slight toxicity. The amount of absorption in blood and the amount of excretion is ur;ne after the administration of the derivatives were detetermined by biological techqnique with the spore of B. subtilis. In the case of oral administration of Panturan-100.2 at the concentration of 100 mg/kg to rabbit, less than I mcg/kg of it was demonstrated in blood 1-1.5 hours after the administration. In urine less than 10 mcg/ml of Panfuran-acetate was demonstrated 1 hour after the administration, but in the case of Panfuran-100.2 more than 10 mcg/ml of it was demonstrated in urine 3 hours after the administration. The bacteriostatic action in vitro against dysentery bacilli isolated from patients was about 0.19 mcg/ml and not a change of action was observed against shigella flexneri and sonnei group or all types of flexneri, group. They were also active to various kinds of antibiotib-resistant dysentery bacilli isolated from patients as well as to antibiotic sensitive strain. Moreover it inhibited the growth of Staphylococci isolated from the infected cases at the cencentration of 0.39 mcg/ml, and E. coli isolated from patients were comparatively sensitive to the derivatives. From the results obtained it might be concluded that the new furan-deriratives have powerful antibacterial action against antibiotics-sensitive and rsistant dysentery bacilli, Staphylococci and E. coli isolated from ratients and no cross-resistance might exist between the new furanderivative and antibiotics.