LEUCOCYTE FUNCTIONS OF PATIENTS UNDERGOING HEMODIALYSIS BY IMMUNOBEADS FOR DIABETES OR CHRONIC NEPHRITIS

• Published in: Journal of The Showa Medical Association Vol. 49; no. 3; pp. 230 - 235
• Main Authors: AOYAGI, Kyoko, TSUJI, Masatomi, NAGANO, Seishi, OHTA, Hideo
• Format: Journal Article
• Language: Japanese
• Published: The Showa University Society 1989
• ISSN: 0037-4342; 2185-0976
• DOI: 10.14930/jsma1939.49.230

The number of diabetic and chronic renal failure patients undergoing hemodialysis is increasing. We examined leucocyte functions of 34 diabetic patients, 6 diabetic patients undergoing hemodialysis, 11 non-diabetic hemodialysis patients, and 19 healthy controls in an attempt to elucidate the origin of the infectious tendency of these patients. We differentiated diabetic patients with proteinuria from those without. Phagocytic and NBT reduction activity of immunobeads were examined at the same time. The order of phagocytic activity was: healthy controls>diabetics>diabetic dialysis>non-diabetic dialysis group. The order of NBT reduction activity was: healthy controls>diabetics=non-diabetic dialysis>diabetic dialysis. Relations were determined between leucocyte functions, other data (age, history of dialysis, etc.), and some laboratory data (creatinine, BUN, etc.) . In diabetics without proteinuria HbA1 score and age were higher, and NBT reduction rate was lower. In the non-diabetic dialysis group creatinine was correlated with both phagocytic and NBT reduction activity. History of dialysis was not related to either diabetics undergoing dialysis or the non-diabetic dialysis group. In the group of 34 diabetic patients there was no clear indication of influence by therapy other than diet or drug therapy.