Synthesis and Immunological Effect of Deacetyl-thymosin α11 on Low E-Rosette-Forming Cells of a Rheumatoid Arthritis Patient

Deacetyl-thymosin α11 was synthesized by successive azide condensations of seven peptide fragments, Boc-(1-3)-NHNH2, Boc-(4-7)-NHNH2, Boc-(8-11)-NHNH2, Boc-(12-16)-NHNH2, Boc-(17-22)-NHNH2, Boc-(23-26)-NHNH2 and Boc-(27-29)-NHNH2, with H-(30-35)-OBzl, followed by deprotection with hydrogen fluoride...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 33; no. 12; pp. 5419 - 5427
Main Authors ABIKO, TAKASHI, SEKINO, HIROSHI
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 25.12.1985
Maruzen
Subjects
Chemistry
Exact sciences and technology
Organic chemistry
Peptides
Preparations and properties
β, β, β-trichloroethoxycarbonylhydrazide
Non steroidal antiinflammatory agent
Liquid phase
Rheumatoid arthritis
Biological activity
Peptide hormone
Rosette test
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Summary:Deacetyl-thymosin α11 was synthesized by successive azide condensations of seven peptide fragments, Boc-(1-3)-NHNH2, Boc-(4-7)-NHNH2, Boc-(8-11)-NHNH2, Boc-(12-16)-NHNH2, Boc-(17-22)-NHNH2, Boc-(23-26)-NHNH2 and Boc-(27-29)-NHNH2, with H-(30-35)-OBzl, followed by deprotection with hydrogen fluoride in the presence of anisole and thioanisole. An increase of E-rosette-forming cells was obtained after incubation of peripheral blood from a rheumatoid arthritis patient with the synthetic deacetyl-thymosin α11. This synthetic deacetyl-thymosin α11 was approximately equal in potency to our synthetic deacetyl-thymosin α1 in cases of rheumatoid arthritis.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.33.5419