Immunological Effect of Two Synthetic Peptides Containing Alanine or D-Alanine Instead of Acetyl Group of Thymosin β4 after Treatment of Human Serum

Two analogs of thymosin β4 the N-terminal acetyl groups of which were substituted by Ala or D-Ala, were synthesized by the solution method and studied for their immunological effect on the impaired blastogenic response of T-lymphocytes isolated from uremic patients after treatment of human serum. On...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 38; no. 9; pp. 2602 - 2605
Main Authors ABIKO, Takashi, SEKINO, Hiroshi
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 25.09.1990
Maruzen
Subjects
Chemistry
dithiothreitol reduction
Exact sciences and technology
human serum treatment
impaired T-lymphocyte blastogenic response
Organic chemistry
Peptides
Preparations and properties
serum stability
thymosin β4 analog synthesis
trifluoromethanesulfonic acid deprotection
Immunomodulator
Oligopeptides
Liquid phase
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Summary:Two analogs of thymosin β4 the N-terminal acetyl groups of which were substituted by Ala or D-Ala, were synthesized by the solution method and studied for their immunological effect on the impaired blastogenic response of T-lymphocytes isolated from uremic patients after treatment of human serum. One of the synthetic analogs, D-Ala-thymosin β4 demonstrated a restorative effect on these patients when incubated in human serum, but the other analog, Ala-thymosin β4, showed no restorative effect under the same conditions. These results seem to suggest that D-Ala-thymosin β4 increases resistance to proteolytic degradation by exopeptidases more than Ala-thymosin β4.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.38.2602