BONE TISSUE CONCENTRATION OF OFLOXACIN

• Published in: CHEMOTHERAPY Vol. 39; no. 10; pp. 976 - 981
• Main Authors: Sano, Eisaku, Otsuka, Yoshiki, Nakasuji, Kanako, Hirano, Fuki, Motoji, Shigeki, Ichii, Masaaki, Kobayashi, Souichirou, Yoshii, Takashi, Nakao, Kaoru, Shimada, Keikichi
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1991
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.39.976

We studied the concentration of ofloxacin, in some tissues, especially bone, and obtained the following results. 1) In rabbits, the areas under the curve (AUC) of tissues, except femoral bone cortex and mandibular bone cortex were all superior to those of serum. The AUG of the submandibular gland was the largest of the soft oral tissues (56.49μg·h/g). Next were the gingiva, and the submandibular lymphnodes. In bone tissues, the AUG of submandibular bone marrow was largest (34.41μg·h/g). The T1/2 of mandibular bone marrow and the cortex were longer than the other tissues. We consider that the concentration of ofloxacin (OFLX) in mandibular bone is maintained over considerable periods. 2) In patients, the concentrations of OFLX in the mandible were 19-53% of serum concentrations. 3) The antibacterial activity of OFLX was inferior to that of ampicillin, but 1 to 2 dilutions superior to that of cefaclor against aerobic Gram-positive bacteria.