RENAL TISSUE CONCENTRATIONS OF CEFMENOXIME

Ten nephrectomy patients were intravenously given a bolus shot of 1.0 g cefmenoxime simultaneously with beginning of operation. The peripheral blood was sampled at the ligation of the renal vessels. Tissue cefmenoxime levels (μg/g) in the excised kidneys varied from 5.56 to 197 at 24 to 145 minutes...

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Published inCHEMOTHERAPY Vol. 33; no. 6; pp. 544 - 547
Main Authors MIYOSHI, SUSUMU, HONDA, MASAHITO, KAJIKAWA, HIROSHI, KAMEOKA, HIROSHI, IWAO, NORIO, MIZUTANI, SHUTARO, SHIBA, KOHJI
Format Journal Article
LanguageJapanese
Published Japanese Society of Chemotherapy 1985
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Summary:Ten nephrectomy patients were intravenously given a bolus shot of 1.0 g cefmenoxime simultaneously with beginning of operation. The peripheral blood was sampled at the ligation of the renal vessels. Tissue cefmenoxime levels (μg/g) in the excised kidneys varied from 5.56 to 197 at 24 to 145 minutes after administration. The ratio of the tissue/serum cefmenoxime levels also varied from 0.262 to 4.79 with mean value of 1.33. The variations were presumed to be due to the difference in degree of the impairment of the renal functions.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.33.544