STUDIES ON MULTIPLE-RESISTANT STAPHYLOCOCCUS AUREUS

• Published in: CHEMOTHERAPY Vol. 35; no. 3; pp. 213 - 218
• Main Authors: WADA, KOUICHI, TAKEDA, HAZIMU, ARAKAWA, MASAAKI, OZAKI, KYOKO, TAKANO, MISAO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1987
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.35.213

In 1985, 45% of Staphylococcus aureus isolated were multiple-resistant S. aureus in our hospital. We investigated the sensitivity of 46 strains against 16 chemotherapeutic agents and the outcome of treatment of 14 episodes of bacteremia, 10 of respiratory infection and 2 of urinary tract infection. These strains were isolated from blood in 13, sputum in 22, urine in 5, pus in 4, bile in 2. As a result, MIC50 of cefazolin, cefmetazole, methicillin, cloxacillin, piperacillin, tobramycin, amikacin, minocycline, doxycycline and fosfomycin was 12.5μg/ml or more. MIC50 of gentamicin and astromicin was 6.25μg/ml or less. These all strains were sensitive against HBK, vancomycin, ofloxacin, sulfamethoxazole-trimethoprim (MIC; 3.13 or less). The patients with multiple-resistant S. aureus infection were mostly in poor condition because of severe underlying disease. Out of 14 bacteremia, 13 patients were inserted vascular catheters. Eighteen patients, out of 26 with multiple-resistant S. aureus infection, were treated with antimicrobial agents thought to be effective in vitro (MIC;≤1.56). Seventeen cases were eradicated in bacteriological effects, but 13 patients died in short term. As clinical effects of antimicrobial agents, HBK was excellent. Vancomycin was also excellent, although azotemia appeared in 2 cases.