CLINICAL EFFECTS OF MICONAZOLE IN PATIENTS WITH MYCOSIS ASSOCIATED WITH VARIOUS HEMATOLOGICAL DISEASES OR WITH PYREXIA RESISTANT TO ANTIBIOTICS

• Published in: CHEMOTHERAPY Vol. 36; no. 1; pp. 19 - 24
• Main Authors: AMANO, MASAMICHI, SAITO, TSUNEHIRO, KURIYA, SHIN-ICHIRO, MASUDA, MICHIHIKO, TAKAKU, FUMIMARO, NOMURA, TAKEO, MITANI, KINUKO, MIZOGUCHI, HIDEAKI, URABE, AKIO, FUJIOKA, SEITOKU, MUTO, YOSHITOMO, TOGAWA, ATSUSHI, YAMAGUCHI, HISOMU
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1988; 公益社団法人 日本化学療法学会
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.36.19

Miconazole, an antimycotic agent was administered to 23 patients with mycosis associated with severe hematological diseases or with pyrexia suspected as being mycotic in order to examine its clinical and side-effects. Subjects were 9 cases of pulmonary mycosis or mycotic pneumonia, 1 case of Candida esophagitis and 13 cases of suspected mycotic sepsis. Miconazole was given by drip infusion 2 or 3 times a day at a dose of 200 to 400mg. Clinical results were remarkably effective in 2, effective in 15, and ineffective in 6 cases, with an efficacy rate of 73. 9%. Side-effects were eruption in 2 and abnormal values of GOT, GPT, γ-GTP, Al-P and LDH in 1. The above results suggest that this preparation is effective against visceral mycosis and antibioticresistant pyrexia of unknown cause.