TETRACYCLINE RESISTANT AND POLYMYXIN B SENSITIVE VIBRIO CHOLERAE O1 EL TOR ISOLATED FROM THE RECENT EPIDEMICS

By examining 99 Vibrio cholerae O1 isolates from cholera epidemics in a variety of areas in Laos in 1998, we found two unusual characteristics of the organisms. All except 4 isolates were moderately resistant to tetracycline without having plasmids, and susceptibilities to the other drugs were as ex...

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Published inJapanese Journal of Tropical Medicine and Hygiene Vol. 28; no. 1; pp. 15 - 18
Main Authors HIGA, NAOMI, IWANAGA, MASAAKI, SISAVATH, LAY, INSISIENGMAY, SITHAT
Format Journal Article
LanguageEnglish
Published Japanese Society of Tropical Medicine 15.03.2000
Subjects
drug sensitivity
Laos
polymyxin B
tetracycline
Vibrio cholerae O1
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ISSN0304-2146
2186-1811
DOI10.2149/tmh1973.28.15

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Summary:By examining 99 Vibrio cholerae O1 isolates from cholera epidemics in a variety of areas in Laos in 1998, we found two unusual characteristics of the organisms. All except 4 isolates were moderately resistant to tetracycline without having plasmids, and susceptibilities to the other drugs were as expected. Eleven isolates showed the same level of susceptibility to polymyxin B as classical V. cholerae O1. With the exception of 4 tetracycline-susceptible strains, all the isolates were resistant to or poorly sensitive to the vibriostatic agent O/129 (2, 4-diamino-6, 7-di-iso-propyl pteridine phosphate). All isolates, including those susceptible to polymyxin B, produced El Tor hemolysin which was neutralized by anti-El Tor hemolysin and were resistant to cholera phage IV, indicating that they were of the El Tor biotype.
ISSN:0304-2146
2186-1811
DOI:10.2149/tmh1973.28.15