TRANSIENT PURE RED CELL APLASIA INDUCED BY HUMAN PARVOVIRUS B19 INFECTION IN A PATIENT WITH MALIGNANT LYMPHOMA ON CHEMOTHERAPY
A 39-year-old man was given chemotherapy for malignant lymphoma in April 1992. He achieved complete remission soon. In January 1993, during the sixth chemotherapy treatment, he became febrile and felt difficulty in breathing. A chest X-ray film revealed abnormal diffuse shadow suggesting pneumonia....
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| Published in | Japanese Journal of National Medical Services Vol. 48; no. 11; pp. 950 - 952 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of National Medical Services
1994
一般社団法人 国立医療学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-1699 1884-8729 |
| DOI | 10.11261/iryo1946.48.950 |
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| Abstract | A 39-year-old man was given chemotherapy for malignant lymphoma in April 1992. He achieved complete remission soon. In January 1993, during the sixth chemotherapy treatment, he became febrile and felt difficulty in breathing. A chest X-ray film revealed abnormal diffuse shadow suggesting pneumonia. He was intubated and controlled by a respirator. After treatment, his pneumonia subsided. On February 1st., he was found to be anemic. Bone marrow puncture showed severe hypoplasia of the erythroid series (erythroblast 0.4%). The diagnosis of pure red cell aplasia (PRCA) was established. The serum was positive for human parvovirus B19 (HPV B19) DNA, using polymerase chain reaction (PCR). Accordingly, he was considered to be suffering from PRCA due to HPV B19 infection. Since then, he was observed without special therapy for PRCA. His anemia improved. If a patient on chemotherapy develops undetermined anemia, we should consider the possibility of HPV B19 infection |
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| AbstractList | A 39-year-old man was given chemotherapy for malignant lymphoma in April 1992. He achieved complete remission soon. In January 1993, during the sixth chemotherapy treatment, he became febrile and felt difficulty in breathing. A chest X-ray film revealed abnormal diffuse shadow suggesting pneumonia. He was intubated and controlled by a respirator. After treatment, his pneumonia subsided. On February 1st., he was found to be anemic. Bone marrow puncture showed severe hypoplasia of the erythroid series (erythroblast 0.4%). The diagnosis of pure red cell aplasia (PRCA) was established. The serum was positive for human parvovirus B19 (HPV B19) DNA, using polymerase chain reaction (PCR). Accordingly, he was considered to be suffering from PRCA due to HPV B19 infection. Since then, he was observed without special therapy for PRCA. His anemia improved. If a patient on chemotherapy develops undetermined anemia, we should consider the possibility of HPV B19 infection A 39-year-old man was given chemotherapy for malignant lymphoma in April 1992. He achieved complete remission soon. In January 1993, during the sixth chemotherapy treatment, he became febrile and felt difficulty in breathing. A chest X-ray film revealed abnormal diffuse shadow suggesting pneumonia. He was intubated and controlled by a respirator. After treatment, his pneumonia subsided. On February 1st., he was found to be anemic. Bone marrow puncture showed severe hypoplasia of the erythroid series (erythroblast 0.4%). The diagnosis of pure red cell aplasia (PRCA) was established. The serum was positive for human parvovirus B19 (HPV B19) DNA, using polymerase chain reaction (PCR). Accordingly, he was considered to be suffering from PRCA due to HPV B19 infection. Since then, he was observed without special therapy for PRCA. His anemia improved. If a patient on chemotherapy develops undetermined anemia, we should consider the possibility of HPV B19 infection 39歳の男性. 平成4年4月悪性リンパ腫に対し化学療法を開始し完全寛解となった. 平成5年第6回目の化学療法中発熱し呼吸困難が強くなった. 胸部X-pで肺炎像を認め翌日挿管し, レスピレーター管理となった. 治療により肺炎は改善した. 2月1日貧血が認められ骨髄穿刺がなされた. 赤芽球0.4%と著明に減少しPRCAと診断した. 当初バクタを疑い投与を中止した. 9日目の骨髄穿刺では赤芽球51%と回復していた. また. 患者血清よりパルボウイルスB19(HPVB19)DNAが検出されたことより貧血はHPVB19感染によるPRCAと考えられた. 以後貧血に対しては無治療で観察されているが, 次第に貧血の改善をみている. 造血器腫瘍の経過中生じた貧血ではHPVBI9感染によるPRCAも考慮すべきである |
| Author | SANADA, Isao KUSUMOTO, Yukihiko KIYOKAWA, Tetsuyuki TSUKAMOTO, Atsuko KAWANO, Fumio SHIDO, Tadahiro |
| Author_FL | SANADA Isao 紫藤 忠博 清川 哲志 楠本 行彦 塚本 敦子 KAWANO Fumio |
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| Author_xml | – sequence: 1 fullname: KAWANO, Fumio organization: Kumamoto National Hospital – sequence: 1 fullname: TSUKAMOTO, Atsuko organization: Kikuchi Keihuen National Sanatorium – sequence: 1 fullname: KIYOKAWA, Tetsuyuki organization: Department of Internal Medicine, Kumamoto National Hospital – sequence: 1 fullname: SHIDO, Tadahiro organization: Department of Internal Medicine, Kumamoto National Hospital – sequence: 1 fullname: SANADA, Isao organization: Department of Internal Medicine, Kumamoto National Hospital – sequence: 1 fullname: KUSUMOTO, Yukihiko organization: Kumamoto Red Cross Blood Center |
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| References | 4) 小林明子: 成人のparvovirusB19感染症に認められた一過性赤芽球磨, 臨血, 34: 484, 1993 2) Kurtzman G et al: Pure red-cell aplasia of 10 years' duration due to persistent parvovirus B19 infection and its cure with immunogloblin therapy. N Engl J Med, 321: 519, 1989 3) Kurtzman GJ et al: Persistant B19 parvovirus infection as a cause of severe chronic anemia in children with acute lymphoytic leukemia. Lancet, 2: 1159, 1988 1) Kellehar JF et al: Human serum “parvovirus”: a specific cause of aplastic crisis in children with hereditary spherocyosis. J Pediatrics, 102: 720, 1983 6) 藤岡宏夫他: 血液悪性腫瘍疾患に対する化学療法中に生じたヒトパルボウイルスB19感染症, 臨血, 34: 28, 1993 5) 斎藤由美子他: ヒトパルボウイルスB19感染へのPCRの応用およびELISAによる抗体測定, 臨病, 41: 203, 1993 |
| References_xml | – reference: 4) 小林明子: 成人のparvovirusB19感染症に認められた一過性赤芽球磨, 臨血, 34: 484, 1993 – reference: 1) Kellehar JF et al: Human serum “parvovirus”: a specific cause of aplastic crisis in children with hereditary spherocyosis. J Pediatrics, 102: 720, 1983 – reference: 6) 藤岡宏夫他: 血液悪性腫瘍疾患に対する化学療法中に生じたヒトパルボウイルスB19感染症, 臨血, 34: 28, 1993 – reference: 2) Kurtzman G et al: Pure red-cell aplasia of 10 years' duration due to persistent parvovirus B19 infection and its cure with immunogloblin therapy. N Engl J Med, 321: 519, 1989 – reference: 3) Kurtzman GJ et al: Persistant B19 parvovirus infection as a cause of severe chronic anemia in children with acute lymphoytic leukemia. Lancet, 2: 1159, 1988 – reference: 5) 斎藤由美子他: ヒトパルボウイルスB19感染へのPCRの応用およびELISAによる抗体測定, 臨病, 41: 203, 1993 |
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| Snippet | A 39-year-old man was given chemotherapy for malignant lymphoma in April 1992. He achieved complete remission soon. In January 1993, during the sixth... |
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| SubjectTerms | chemotherapy human parvovirus B19 immunodef iciency malignant lymphoma pure red cell aplasia ヒトパルボウイルスB19 免疫不全 化学療法 悪性リンパ腫 赤芽球癆 |
| Title | TRANSIENT PURE RED CELL APLASIA INDUCED BY HUMAN PARVOVIRUS B19 INFECTION IN A PATIENT WITH MALIGNANT LYMPHOMA ON CHEMOTHERAPY |
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