TRANSIENT PURE RED CELL APLASIA INDUCED BY HUMAN PARVOVIRUS B19 INFECTION IN A PATIENT WITH MALIGNANT LYMPHOMA ON CHEMOTHERAPY

A 39-year-old man was given chemotherapy for malignant lymphoma in April 1992. He achieved complete remission soon. In January 1993, during the sixth chemotherapy treatment, he became febrile and felt difficulty in breathing. A chest X-ray film revealed abnormal diffuse shadow suggesting pneumonia....

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Bibliographic Details
Published inJapanese Journal of National Medical Services Vol. 48; no. 11; pp. 950 - 952
Main Authors SANADA, Isao, TSUKAMOTO, Atsuko, KIYOKAWA, Tetsuyuki, KAWANO, Fumio, SHIDO, Tadahiro, KUSUMOTO, Yukihiko
Format Journal Article
LanguageJapanese
Published Japanese Society of National Medical Services 1994
Subjects
chemotherapy
human parvovirus B19
immunodef iciency
malignant lymphoma
pure red cell aplasia
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Summary:A 39-year-old man was given chemotherapy for malignant lymphoma in April 1992. He achieved complete remission soon. In January 1993, during the sixth chemotherapy treatment, he became febrile and felt difficulty in breathing. A chest X-ray film revealed abnormal diffuse shadow suggesting pneumonia. He was intubated and controlled by a respirator. After treatment, his pneumonia subsided. On February 1st., he was found to be anemic. Bone marrow puncture showed severe hypoplasia of the erythroid series (erythroblast 0.4%). The diagnosis of pure red cell aplasia (PRCA) was established. The serum was positive for human parvovirus B19 (HPV B19) DNA, using polymerase chain reaction (PCR). Accordingly, he was considered to be suffering from PRCA due to HPV B19 infection. Since then, he was observed without special therapy for PRCA. His anemia improved. If a patient on chemotherapy develops undetermined anemia, we should consider the possibility of HPV B19 infection
ISSN:0021-1699
1884-8729
DOI:10.11261/iryo1946.48.950