DEVELOPMENT OF BLOOD PRESSURE CONTROL SYSTEM

• Published in: Jinko Zoki Vol. 22; no. 3; pp. 1009 - 1013
• Main Authors: SAKAMOTO, Tadahiro, MAETANI, Shunzou, ONODERA, Hisashi, FURUTANI, Eiko, ARAKI, Mituhiko
• Format: Journal Article
• Language: Japanese
• Published: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS 1993; 一般社団法人 日本人工臓器学会
• Subjects: antihypertensive agents; closed-loop blood pressure control system; state-predictive control method
• ISSN: 0300-0818; 1883-6097
• DOI: 10.11392/jsao1972.22.1009

We developed a computerized automatic blood pressure control system. Using the state predictive control theory, blood pressure was controlled by adjusting the infusion rates of antihypertensive agents and saline solusion. The agents used were trimethaphan camsilate, PGE1 and nicardipine. The fidelity of the system was evaluated in trimethaphan- treated dogs which were anesthesized with GOF under controlled respiration. When the target MAP (mean arterial pressure) was set at 80mmg, it was reached in 5 to 30 minutes. The duration of error from the target MAP±10% was 3.695±4.54min/hr (n=9) and the integral of the error was 1.142±0.185mmHghr/hr (Mean±SD, n=9). These results indicated the safety and stability of our system.