Three Cases of Sarcoidosis Associated with Multiple Cancer

• Published in: NIHON SARUKOIDOSHISU / NIKUGESHUSHIKKAN (The Japanese journal of sarcoidosis and other granulomatous disorders ) Vol. 19; no. 1; pp. 39 - 44
• Main Authors: Kataoka, Mikio, Tanimoto, Yasushi, Kimura, Goro, Takao, Kazushi, Nakata, Yasunari, Kamao, Takayuki, Tada, Shinya, Harada, Mine, Hiramatsu, Jun-ichi, Takeda, Katsuyuki
• Format: Journal Article
• Language: Japanese
• Published: Japan Society of Sarcoidosis and other Granulomatous Disorders 1999; 日本サルコイドーシス/肉芽腫性疾患学会
• Subjects: Malignacy; Multiple cancer; Sarcoidosis; サルコイドーシス; 多重癌; 悪性腫瘍
• ISSN: 1345-0565; 1884-6122
• DOI: 10.14830/jssog1999.19.39

For the last two decades, the association between sarcoidosis and malignancy has been disputed. We evaluated the occurrence and type of malignancy on the basis of data among 249 patients with sarcoidosis for a total of 3292 personyears presenting at Okayama University Hospital. Ten patients had 14 sites and 10 types of malignancies. In those, three patients had double or triple cancer in the course of sarcoidosis. Case 1 had chronic lymphocytic leukemia (B cell type, IgMλ) and lung cancer (squamous cell carcinoma, stage I). Case2 had gastric cancer and colon cancer. Case 3 had basal cell carcinoma of the skin on the nose, Bowen's disease of the foot and non-Hodgkin's lymphoma (diffuse, large cell type, clinical stage IV). We found three cases developing double or triple cancer. These cases may suggest relationship between sarcoidosis and malignancy.