EXPERIMENTAL STUDY OF ARTIFICIAL PLACENTA; DOPPLER ECHO CARDIOGRAPHIC EVALUATION OF GOAT FETAL BLOOD FLOW

• Published in: Jinko Zoki Vol. 22; no. 3; pp. 880 - 884
• Main Authors: SAKATA, M., HISANO, K., YOKOYAMA, N., NAKAMURA, H., OKADA, M., NOMA, O., UETANI, Y.
• Format: Journal Article
• Language: Japanese
• Published: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS 1993; 一般社団法人 日本人工臓器学会
• Subjects: A-V ECMO; artificial placenta; Doppler ultrasonography; fetal surgery; prenatal diagnosis
• ISSN: 0300-0818; 1883-6097
• DOI: 10.11392/jsao1972.22.880

An experimental study of fetal incubation in artificial amniotic fluid was performed. Ten goat fetuses obtained by caesarian incision (average gestational age was 125 days) underwent cannulation through the umbilical arteries and veins. ECMO circuits contained hollowfiber type membrane oxygenators (0.5m2) and autoregulating sensors. The fetuses were incubated in an artificial amniotic fluid made by the authors, and which has the same contents as goat amniotic fluid. A-V shunts were performed by a conventional roller pump until cardiac arrest. The duration of ECMO perfusion in each case ranged from 4 to 109 hours. During ECMO perfusion, colour Doppler ultrasonographic examinations showed the persistence of fetal circulation through the ductus arteriosus and foramen ovale. Hemodynamics of the fetus undergoing incubation depended on the perfusion rate of ECMO. On A-V ECMO for fetuses, it was advantageous to obtain a flow rate from 80 to 100ml/kg/min.