Two Elderly Cases of Allergic Granulomatosis and Angiitis (AGA)

• Published in: NIHON SARUKOIDOSHISU / NIKUGESHUSHIKKAN (The Japanese journal of sarcoidosis and other granulomatous disorders ) Vol. 21; no. 1; pp. 91 - 95
• Main Authors: Maniwa, Ko, Taguchi, Yoshio, Oida, Kazukiyo, Kohri, Yoshiaki, Tanaka, Eisaku, Inoue, Tetsuro, Kato, Terufumi, Sakuramoto, Minoru, Maeda, Yuji, Hamanishi, Tohru, Nishio, Chihiro, Noma, Satoshi, Miyagawa, Aya, Yuba, Yoshiaki, Kobashi, Yoichiro
• Format: Journal Article
• Language: Japanese
• Published: Japan Society of Sarcoidosis and other Granulomatous Disorders 2001
• Subjects: Allergic Granulomatosis and Angiitis (AGA); ANCA (Anti-Neutrophil Cytoplasmic Antibody); Elderly cases; Infiltration by eosinophils; Prognosis
• ISSN: 1345-0565; 1884-6122
• DOI: 10.14830/jssog1999.21.91

Two elderly cases of allergic granulomatosis and angiitis (AGA) were reported, whose histological diagnosis could be obtained. Tests for MPO-ANCA were both negative. One case, an 84-year-old-woman, was treated by corticosteroid and immunosuppressive agents, and the other case, an 82-year-old woman, was treated by corticosteroid. The former case died from opportunistic infection, the latter became unconscious with central nervous system vasculitis by withdrawing corticosteroid during tapering. It is known that AGA, associated with MPO-ANCA, has a tendency to occur in more juvenile ages than the other vasculitises and that its prognosis is relatively good among them. But both of our two cases were in trouble on their clinical course. Because elderly cases of AGA are rare, we suggest that the further global investigations of AGA are recommennded.