A CASE OF THE PULMONARY TUBERCULOSIS COMPLICATED WITH RIFAMPICIN INDUCED ACUTE INTERSTITIAL NEPHRITIS

• Published in: Japanese Journal of National Medical Services Vol. 49; no. 9; pp. 765 - 768
• Main Authors: KUDOH, Koichiro, SHINBARA, Ayako, TOYODA, Emiko, SAIMA, Shigeki, TOH, Yasuo, KAMIMURA, Mitsuhiro, SUGIYAMA, Haruhito, KAWAS, Ryuji, KABE, Jyunzaburou
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of National Medical Services 1995; 一般社団法人 国立医療学会
• Subjects: acute interstitial nephritis; continuous administration; Rifampicin (RFP); リファンピシン; 急性間質性腎炎; 連続投与
• ISSN: 0021-1699; 1884-8729
• DOI: 10.11261/iryo1946.49.765

We reported a patient who developed interstitial nephritis due to Rifampicin (RFP) administration for pulmonary tuberculosis. The patient was a 54 year-old man who was treated for tuberculosis with combination therapy composed of INH 0.3g, RFP 0.45g, EB 1.0g and PZA 1.2g (all per day). After a couple of months, he suffered from renal dysfunction. Discontinuation of all drugs made him improve soon. We performed renal biopsy one month later, which revealed acute interstitial nephritis. After confirming improvement of renal function, we re-started drugs except for RFP. No recurrence of the impaired renal function was noted. Therefore we suspected RFP as the cause of nephritis. According to the previous reports, the risk of RFP-induced interstitial nephritis tends to occur when administered intermittently or repeatedly. However, the attention should be paid to the risk of nephritis even if regular use of it. When treating tuberculosis with the continuous administration of RFP, if we should remind renal complications.