Development of Simultaneous Analysis of Pharmaceuticals in Aqueous Samples Using LC-MS/MS

• Published in: ENVIRONMENTAL ENGINEERING RESEARCH Vol. 43; pp. 73 - 82
• Main Authors: NAKADA, Norihide, KOMORI, Koya, TANAKA, Hiroaki, HOWA, Isao, SUZUKI, Yutaka, KONISHI, Chie
• Format: Journal Article
• Language: English; Japanese
• Published: Japan Society of Civil Engineers 2006; 公益社団法人 土木学会
• Subjects: LC-MS/MS; Pharmaceuticals; River water; Simultaneous analysis
• ISSN: 1341-5115; 1884-829X
• DOI: 10.11532/proes1992.43.73

In recent years, pharmaceuticals have attracted attention as new environmental contaminants. Their detections in the aqueous environment thanks to innovative analytical methods have been extensively reported in Europe and North America. The purpose of this study is to develop an innovative and timesaving method to analyze many pharmaceuticals in water samples by solid phase extraction and LC-MS/MS. In this study, the recoveries and the efficiencies of both extraction and ionization were evaluated in comparison with between an absolute calibration curve method and a “standard addition method at a single concentration.” The results showed that the standard addition method can correct more appropriately measurement values biased due to the extraction and ionization processes. Detection limits of 58 pharmaceuticals are between 0.66 to 59 ng/1 for a concentration factor of 200. Therefore, this method is useful for simultaneous analysis of pharmaceuticals in the aqueous environment.