EXPERIMENTAL STUDY OF ARTIFICIAL PLACENTA; DOPPLER ECHOCARDIOGRAFHIC EVALUATION OF GOAT FETAL DUCTAL BLOOD VELOCITY AND WAVEFORMS IN ARTIFICAL PLACENTA

• Published in: Jinko Zoki Vol. 23; no. 3; pp. 921 - 924
• Main Authors: UETANI, Y, OKADA, M, NOMA, O, SAKATA, M, YOKOYAMA, N, NAKAMURA, H, YASUFUKU, M, HISANO, K
• Format: Journal Article
• Language: Japanese
• Published: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS 1994; 一般社団法人 日本人工臓器学会
• Subjects: A-V shunt; artifical placenta; Doppler echocardiografhy; ductus arteriosus; fetal surgery
• ISSN: 0300-0818; 1883-6097
• DOI: 10.11392/jsao1972.23.921

An experimental study of fetal incubation in artificial placenta was performed. Four goat fetuses obtained by caesarian incision (average gestational term was 110-136 days) underwent cannulation through the umbilical arteries and vein. A-V shunt circuits consisted of 0.2m2 polyolefin membrane oxygenator, roller pump, cannulas, and tubes which were found in routine neonatal ECMO, and was autoregulated. Cannulations were achieved via the umbilical artery and vein. The fetuses were incubated in artificial amniotic fluid which had the same contents as goat amniotic fluid. The duration of ECMO perfusion ranged from 3 to 70 hours with mean of 40 hours. During ECMO perfusion, ductus arteriosus and fetal ductal blood velocity waveforms were evaluated with pulse Doppler echocardiography. Ductal occlusion and stenosis change the blood velocity waveforms, and early death. Subsequently wide open ductus led to good result. Doppler echocardiographic evaluation was the best way for assessment of fetal circulation in artificial placenta.