COMPARATIVE EVALUATION OF COTTON-LIKE FIBROUS COLLAGEN HEMOSTATS MADE FROM HEAT-DEHYDRATION CROSS -LINKED COLLAGEN

We manufactured four types of cotton-like collagen hemostat which were made from atelocollagen fibers cross-linked by heat dehydration for use as topical hemostatic agents. Their fibers were 1) 15-25μm in diameter, 0.5 cm in length, 2)15-25μm in diameter, 1.0 cm in length, 3) 15-25μ m in diameter, 3...

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Published inJinko Zoki Vol. 27; no. 1; pp. 262 - 268
Main Authors YAMAMOTO, Y., MATSUMOTO, K., UEDA, K., LIU, Y., SEKINE, T., KIYOTANI, T., TAKIMOTO, Y., NAKAMURA, T., SHIMIZU, Y.
Format Journal Article
LanguageJapanese
Published JAPANESE SOCIETY FOR ARTIFICIAL ORGANS 1998
Subjects
fibrous collagen
heat dehydration
hemostasis efficiency
hemostats
oxycellulose
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Summary:We manufactured four types of cotton-like collagen hemostat which were made from atelocollagen fibers cross-linked by heat dehydration for use as topical hemostatic agents. Their fibers were 1) 15-25μm in diameter, 0.5 cm in length, 2)15-25μm in diameter, 1.0 cm in length, 3) 15-25μ m in diameter, 3.0 cm in length, and 4) 20-40μm in diameter, 3.0 cm in length. The hemostatic efficacies of these four hemostats were compared with a commercially available collagen hemostat ( Integran®) and oxycellulose ( Oxycel®) in the canine spleen under normal or low blood pressure. It was found that;type 4) and Oxycel® showed complete hemostasis under both normal and low blood pressure, and that Type 3) showed complete hemostasis only under low blood pressure. Type 4) showed higher hemostatic efficiency than Integran®or Oxycel®. The hemostasis rates of our hemostats were higher than those of Oxycel® within 3 min. after attachment of the hemostats. Tissue reaction to these collagen hemostats was minimal at two weeks after implantation.
ISSN:0300-0818
1883-6097
DOI:10.11392/jsao1972.27.262