Temafloxacin in the treatment of patients with surgical infections

• Published in: CHEMOTHERAPY Vol. 41; no. Supplement5; pp. 643 - 661
• Main Authors: Morimoto, Ken, Kinoshita, Hiroaki, Nakatani, Shuichi, Ueda, Takami, Fujimoto, Mikio, Ohno, Koh-ichi, Hirata, Sanae, Yamazaki, Osamu, Doi, Susumu, Kubo, Shoji
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 25.12.1993
• Subjects: Quinolones; temafloxacin
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.41.Supplement5_643

We gave temafloxacin (TMFX)(300 mg) orally to six patients with T-tube drainage after choledocholithotomy and studied the pharmacokinetics of the drug. Levels of the drug in serum and bile were high for long periods. The peak level in serum, 1.54-3.98 μg/ml, was reached at 2-8 hours, and decreased to 1.24 μg/ml or less at 24 hours, in the six patients. The peak level in bile, 9.1-27.6 μg/ml, was reached at 2-8 hours, and decreased to 1.4-7.3 μg/ml at 12-24 hours. We treated 57 surgical infections with the same drug and evaluated its clinical effects. The clinical efficacy of the drug was excellent in 21 patients, good in 25, fair in 10, and poor in one patient, an efficacy rate of 81%. Efficacy was excellent in seven of the 11 patients with mild infections, a significantly larger fraction than for the patients with moderate or serious infections (p=0.046). The bacteriological response could be evaluated in 41 of the 57 infections. The bacteria were eradicated in 38 patients, decreased in two patients, and replaced in one patient, an eradication rate of 95%. The bacteriological response for each organism isolated (54 bacterial strains) was evaluated. Fifty-two strains were eradicated, one strain decreased, and one strain persisted, an eradication rate of 96%. The MIC levels were calculated in 53 of the bacterial strains isolated. Forty-nine (92%) of the MICs were 6.25 μg/ml or less. MICs for one strain of Staphylococcus aureus, one strain of coagulase-negative staphylococci, one strain of Enterococcus faecalis and onestrain of Pseudomonas aeruginosa, were 12.5 μg/ml or more. Nausea was reported by an 81-yearold woman. The drug seemed to be effective for patients with surgical infections of mild severity.