FUNDAMENTAL AND CLINICAL STUDIES OF CEFPIRAMIDE (SM-1652)

• Published in: CHEMOTHERAPY Vol. 31; no. Supplement1; pp. 516 - 527
• Main Authors: OKADA, KEISHI, MURAKAMI, YASUHIDE, KINOSHITA, HIDECHIKA, KAWASHIMA, TOSHIFUMI, SHIRAMIZU, MIKI, KAWAMURA, NOBUO, OHKOSHI, MASAAKI
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 30.05.1983
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.31.Supplement1_516

MICs of cefpiramide (CPM, SM-1652) on clinically isolated organisms kept in our laboratory were determined, and compared with those of cefotaxime, cefoperazone, cefotiam, cefotetan and cefsulodin. Cefpiramide showed better antibacterial activity against P. aeruginosa than cefsulodin, 2 to 3 tubes weaker activity against E. coli and K. pneunzoniae than cefoperazone, and similar antibacterial activity against S. epiderrnidis to cefoperazone, but was not effective on S. marcescens and C. freundii in comparison with other compounds. For the studies of absorption and excretion, cefpiramide was given to the healthy subjects at doses of 1g and 2g by intravenous drip infusion, 500mg by intramuscular injection and 500mg by intravenous bolus injection, cefazolin at a dose of 500mg was also given for a comparison. The T1/2 of cefpiramide was 4.1-5.2 hrs. and that of cefazolin was 1.85 hrs. Recovery rate of cefpiramide into urine was about 20% for 24 hrs., and that of cefazolin was 85.3%. Among these healthy subjects, 2 of 4 showed disulfiram-like reaction 2 days after the administration of cefpiramide. Clinical effects of cefpiramide based in the criteria of UTI committee resulted in good 6 cases out of 9, and effective rate 67%. Bacteriologically, 10 (83%) out of 12 strains were eradicated. As to side effects, slight elevation of GOT and GPT was observed in one case among 11 cefpiramide treated patients, but disappeared within 1 week after the stoppage of administration. From the results, it was considered that cefpiramide is a useful drug for urinary tract infections in spite of some prohibition of combined use with a few infusion solution and occurrence of disulfiramlike reaction, since it shows strong antibacterial activity against P. aeruginosa and some effectiveness on GPC.