CLINICAL STUDIES ON AB-206

• Published in: CHEMOTHERAPY Vol. 26; no. Supplement4; pp. 246 - 251
• Main Authors: MURAKI, RYOICHI, IMADAKA, KUNIO, FUJII, TOSHIHIRO, NAKANO, MASATO, TAKIZUKA, HISASHI, KANAI, YOSHICHIKA, OKAYAMA, KENICHI, KATSU, MASATAKA
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 25.09.1978
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.26.Supplement4_246

AB-206 was used in the treatment of various infections listed below with the following results: AB-206 was found to be effective in 1 case of acute pharyngitis, 7 out of 11 cases of acute bronchitis, 1 case each of chronic bronchitis and acute pneumonia, 19 out of 21 cases of acute colitis, 2 cases of acute cystitis, 4 out of 7 cases of acute pyelonephritis, and 2 cases of chronic pyelonephritis, while it was ineffective for chronic cystitis. As a whole, 37 out of a total of 47 cases responded to AB-206, giving an efficacy rate of 79%. When these results were inspected by the causative organisms isolated, AB-206 was active against 5 of 7 strains of E. coli, 2 of 3 strains of Klebsiella and 1 strain each of Pseudomonas and Enterobacter. As the side effects, in 1 case dizziness developed and in another case dizziness, nausea and malaise appeared. Laboratory findings revealed abnormalities of liver functions in 2 cases and those of the renal functions in 1 case.