7432-S IN OBSTETRICS AND GYNECOLOGY

We performed basic and clinical studies on 7432-S, a new cephem antibiotic, in obstetrics and gynecology, and obtained the following results. 1) Toleration by uterine tissues and adnexa was good, comparable with that for other cephalosporins. The range of Cmax values was 1.13-1.84 μg/g and Tmax was...

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Published inCHEMOTHERAPY Vol. 37; no. Supplement1; pp. 579 - 587
Main Authors IMAGAWA, NOBUYUKI, HAYASHI, SIGEOKI, HAYASHI, MOITIROO, YAMATO, TATSUO, OBATA, ISAO, KOIKE, KIYOHIKO
Format Journal Article
LanguageJapanese
Published Japanese Society of Chemotherapy 30.11.1989
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ISSN0009-3165
1884-5894
DOI10.11250/chemotherapy1953.37.Supplement1_579

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Summary:We performed basic and clinical studies on 7432-S, a new cephem antibiotic, in obstetrics and gynecology, and obtained the following results. 1) Toleration by uterine tissues and adnexa was good, comparable with that for other cephalosporins. The range of Cmax values was 1.13-1.84 μg/g and Tmax was 3.34-3.57 h after a single oral administration of 100 mg. 2) We also administered the drug to 21 patients with obstetric and gynecological infections.(acute endometritis 5, acute adnexitis 14, and Bartholin's abscess 2, Efficacy was good in all cases (efficacy rate 100%). 3) In a bacteriological study, 19 strains were isolated from 21 cases. Seventeen of 21 strains were eradicated, the eradication rate being 89.5%. 4) There were no side effects or abnormal laboratory findings.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.37.Supplement1_579