Basic and clinical studies of S-1108 in the field of obstetrics and gynecology
Basic and clinical studies were performed, and the following results were obtained. S-1108, a new oral cephem antibiotic, was evaluated for its tissue concentration in female genital organs after administration of 100 and 200 mg doses (n=10). The peak serum levels in uterine artery and cubital vein...
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| Published in | CHEMOTHERAPY Vol. 41; no. Supplement1; pp. 589 - 593 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of Chemotherapy
30.06.1993
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| Online Access | Get full text |
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| Abstract | Basic and clinical studies were performed, and the following results were obtained. S-1108, a new oral cephem antibiotic, was evaluated for its tissue concentration in female genital organs after administration of 100 and 200 mg doses (n=10). The peak serum levels in uterine artery and cubital vein blood were 0.34μg/ml at 3 hours after the 100 mg dose, while genital tissue levels were 0.06-0.18μg/g. After administration of 200mg, serum levels and genital tissue levels were 0.24-0.44μg/ml and 0.12-0.17μg/g respectively at 4 hours. In clinical studies, S-1108 was administered to 9 patients (endometritis: 2, bartholinitis: 1, abscess of bartholin: 1, mastitis: 4, abscess of genitals: 1). The daily dose was 100mg three times a day. The total clinical efficacy rate was 8/9, and the bacteriological effect showed all organisms isolated (5 strains) eradicated after treatment. No serious adverse effects were observed in any of the cases. |
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| AbstractList | Basic and clinical studies were performed, and the following results were obtained. S-1108, a new oral cephem antibiotic, was evaluated for its tissue concentration in female genital organs after administration of 100 and 200 mg doses (n=10). The peak serum levels in uterine artery and cubital vein blood were 0.34μg/ml at 3 hours after the 100 mg dose, while genital tissue levels were 0.06-0.18μg/g. After administration of 200mg, serum levels and genital tissue levels were 0.24-0.44μg/ml and 0.12-0.17μg/g respectively at 4 hours. In clinical studies, S-1108 was administered to 9 patients (endometritis: 2, bartholinitis: 1, abscess of bartholin: 1, mastitis: 4, abscess of genitals: 1). The daily dose was 100mg three times a day. The total clinical efficacy rate was 8/9, and the bacteriological effect showed all organisms isolated (5 strains) eradicated after treatment. No serious adverse effects were observed in any of the cases. |
| Author | Matsuda, Seiji Oh, Kinki Hirayama, Hiroaki |
| Author_xml | – sequence: 1 fullname: Matsuda, Seiji organization: Department of Obstetrics and Gynecology, Koto Hospital – sequence: 2 fullname: Oh, Kinki organization: Department of Obstetrics and Gynecology, Koto Hospital – sequence: 3 fullname: Hirayama, Hiroaki organization: Department of Obstetrics and Gynecology, Koto Hospital |
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| References | 9) 松田静治, 鈴木正明, 王欣暉, 二宮敬宇: NY-198の産婦人科領域における基礎的・臨床的検討. Chemotherapy 36 (S-2): 1085-1090, 1988 1) 久保田忠俊, 石倉公二, 南恭二, 元川清治, 中清水弘. 田中守, 三市能之, 羽島誠: 新経口セフェムS-1108および関連化合物の合成と構造活性相関. 日本薬学会第111年会, 東京, 1991 7) 松田静治, 他 (8施設): 産婦人科領域におけるCS-807の臨床応用. Chemotherapy 36 (S-1): 907-917, 1988 3) Yoshida T, Hamashima T, Komatsu Y, Nomura K, Kuwahara S: 5-1108, a New Oral Cephem: Antibacterial activity. 29th ICAAC, Abstr. No.368, Houston, Sep, 17-20, 1989 4) Yokota T, Arai K: S-1108: Antibacterial activity, stability to β-lactamase, affinity to bacterial penicillin-binding proteins, and synergy of bactericidal effect with serum complement or mousecultured macrophage of its active form, S-1006. 30 th ICAAC, Abstr. No.656, Atlanta, Oct. 21-24, 1990 8) 松田静治, 鈴木正明, 王欣暉: 産婦人科領域におけるCefdinirの臨床応用. Chemotherapy 37 (S-2): 915-921, 1989 10) 松田静治, 鈴木正明, 宮崎亮一郎, 王欣曜: 塵婦人科領域におけるT-3262の臨床応用. Chemotherapy 36 (S-9): 1209-1213, 1988 5) 由良二郎, 齋藤篤: 第40回日本化学療法学会総会, 新薬シンポジウム. S-1108, 名古屋, 1992 2) Nakashima M, Matsuno S, Yoshida T, Kimura Y, Oguma, Ishi H: Pharmacokinetics and safety of S-1108 in healthy volunteers, 29th ICAAC, Abstr. No.370, Houston, Sep. 17-20, 1989 6) 松田静治, 柏倉高, 鈴木正明: T-2588の産婦人科領域における臨床応用. Chemotherapy 34 (S-2): 850-853, 1986 |
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| Title | Basic and clinical studies of S-1108 in the field of obstetrics and gynecology |
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