STUDIES ON CEFAMANDOLE IN THE SURGICAL FIELD

• Published in: CHEMOTHERAPY Vol. 27; no. Supplement5; pp. 409 - 415
• Main Authors: YAMADA, YOSHINARI, SAITO, TOSHIAKI
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 25.06.1979
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.27.Supplement5_409

Brief summaries of our studies on cefamandole, a new semisynthetic cephalosporin, were given as follows. 1) 6 hour's absorption and excretion profiles of 1 g (15.4 mg/kg) iv of CMD were determined in a case with choledocholithiasis, presenting normal liver function, who had underwent cholecystectomy and choledochotomy 3 weeks prior to this study. Every samples were obtained at 30 min., 1, 2, 4, 6 hours after dosing. The samples were prepared in frozen condition immediately. The bile was sampled from BULAU'S drain with a 10# FOLEY'S indwelling catheter, which was put in proximal portion of common bile duct through the T-tube under the fluoroscopic guidance. The administratlon of cefaniandole by iv yielded 63.8 mg/ml of cefamandole in serum, at 30 min. but these concentration fell rapidly thereafter. The highest concentration of 144.9μg/ml in bile was observed at 2 hours after administration of the drug. The biliary recovery of the drug within 2 hours was only 0.37%, and remained 5.080 p, g (0.51% of the dose) during 6 hours. Urinary recovery within 6 hours was 98% of the dose. 2) Therapeutic outcome of cefamandole therapy was studied in 13 patients (cholecystitis: 3, carbuncle; 2, abscess with SCHLOFFE'S tumor: 2, periproctal abscess: 4, localized peritonitis: 2). Clinical response was good or fair in 10 cases. 3) Adverse effect was not shown clinically, but in one case S-GOT and S-GPT elevated after administration of cefamandole for 7 days. Results of COOMBS' test were all negative in 5 cases including the case mentioned above.