Acute Myelogenous Leukemia (FAB : MO) after Spontaneous Remission of Pancytopenia

• Published in: The Japanese Journal of Pediatric Hematology Vol. 10; no. 1; pp. 42 - 45
• Main Authors: HIRAYAMA, Kiyotake, CHINA, Kohichiro, GUSHIKEN, Toshiki, HYAKUNA, Nobuyuki
• Format: Journal Article
• Language: Japanese
• Published: THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY 1996; 特定非営利活動法人 日本小児血液・がん学会
• Subjects: 47; M0 leukemia; platelet peroxidase; spontaneous remission of pancytopenia; t (7; 12); XY
• ISSN: 0913-8706; 1884-4723
• DOI: 10.11412/jjph1987.10.42

A ten-month-old boy was admitted to our hospital for pancytopenia. On admission, his white blood cell count was 2, 630/, μl, his hemoglobin level was 7.4g/dl, and his platelet count was 16, 000/μl. The bone marrow examination showed 7.4% blastic cells. However, one month after the admission, the pancytopenia was resolved and blastic cells in the bone marrow disappeared without specific treatment. One month after discharge, the patient was readmitted for a perianal abscess. On second admission, his white blood cell count was 6, 900/μl with 21% blastic cells. In the bone marrow, there were 26% blastic cells, which registered negative on the myeloperoxidase stain, but registered positive for CD13 and CD33. Chromosomal examination of blastic cells showed 47, XY, t (7 ; 12), + 19. Characteristically, 17% of the blastic cells were positive with platelet peroxidase. The diagnosis was MO according to the FAB classification. Complete remission was attained by chemotherapy with pirarubicin, vincristine and cytarabine. Spontaneous remission of pancytopenia before overt leukemia is unusual. Such a clinical course is similar to some cases of M7 leukemia. We suggest that some of M0 leukemia have similar findings of M7 leukemia.