Urinary excretion of erythromycin and vinblastine in bile duct ligated rats

• Published in: Tando Vol. 16; no. 5; pp. 387 - 391
• Main Authors: TAKADA, Yukiko, TANAKA, Hiroyuki, HOJO, Makoto, MARUMO, Tatsuyuki, KURIHARA, Hiroko, TAKAYANAGI, Motoe, SASAMOTO, Takahiro, Aiso, Mitsuhiko, TAKAMORI, Yoriyuki, TAKIKAWA, Hajime
• Format: Journal Article
• Language: Japanese
• Published: Japan Biliary Association 2002
• Subjects: erythromycin
• ISSN: 0914-0077; 1883-6879
• DOI: 10.11210/tando1987.16.5_387

In patients with complete bile duct obstruction, the only pathway of the elimination of cholephilic compounds is through the urine. Although the changes of various transporters in the liver and kidney in cholestasis have been elucidated, little is known about how effectively the elimination of these compounds is compensated by the urinary excretion. Therefore, in the present study, the urinary excretion of cationic compounds was compared in bile duct-ligated rats for 3 days (BDL). Among organic cations, erythromycin (49±5.2% in BDL vs 19±3.6% in controls) was more effectively excreted into the urine than vinblastine (18.2±4.7% in BDL vs 7.4±2.2% in controls)in BDL. Although the elimination of the cholephilic compounds was compensated by the urinary excretion in BDL, the degree of the urinary excretion was different between cholephilic organic cations.