IN VITRO ANTIBACTERIAL ACTIVITY OF 7432-S, A NEW ORAL CEPHALOSPORIN AGAINST ENTEROPATHOGENIC BACTERIA

• Published in: CHEMOTHERAPY Vol. 37; no. Supplement1; pp. 72 - 77
• Main Authors: GOTO, NOBUICHI, HORIUCHI, SANKICHI, INAGAKI, YOSHIO, CHARUAY, EKATAKSIN, HIGAKI, MEGUMU, TAKANO, HIDEKO, OGAWA, MASAYUKI, NAKAYA, RINTARO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 30.11.1989
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.37.Supplement1_72

Minimum inhibitory concentrations (MICs) of 7432-S, a newly developed oral cephalosporin, were determined against 136 strains of Shigella spp., 55 of Salmonella spp., 33 of Escherichia coli, 24 of Campylobacter spp., 12 of Vibrio parahaemolyticus and 10 of V. cholerae, and compared with those of cefixime (CFIX), enoxacin (ENX), and nalidixic acid (NA). The MICs of 7432-S which inhibited 90% of the strains (MIC90) were 0.20 μg/ml against Shigella spp., 0.10μg/ml against Salmonella spp., 0.39 μg/ml against E. coli, 50 μg/ml against Campylobacter spp., 0.78 μg/ml against V. parahaemolyticus, and 0.20 μg/ml against V. cholerae. These values were mostly half those of CFIX, another oral cephalosporin, except against Vibrios, for which the former was four times higher than the latter. MIC90s of 7432-S were mostly higher than those of ENX, except against Salmonella spp., which was one quarter that of ENX, and against Shigella spp., which was equal. MIC90s of 7432-S were lower than those of NA, except against Campylobacter spp., for which those of cephalosporins were higher. To 7432-S, more than 90% of the Campylobacter strains (MIC, ≥6.25 μg/ml) and one strain of Shigella sonnei (MIC, 25μg/ml) were moderately resistant.