Comparative study of squamous intraepithelial lesion detection and unsatisfactory rates between liquid-based cytology and conventional smears from a split sample in cervical cancer screening: A Japanese experience
In this study, we analyzed the detection rates of squamous intraepithelial lesions (SILs) using BD SurePathTM liquid-based cytology (LBC) and conventional cytology with Cervex-Brush® performed for cervical cancer screening. The split-sample procedure involved direct sampling and spreading with Cerve...
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Published in | Japanese Journal of Medical Technology Vol. 68; no. 1; pp. 19 - 25 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English Japanese |
Published |
Japanese Association of Medical Technologists
25.01.2019
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Subjects | |
Online Access | Get full text |
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Summary: | In this study, we analyzed the detection rates of squamous intraepithelial lesions (SILs) using BD SurePathTM liquid-based cytology (LBC) and conventional cytology with Cervex-Brush® performed for cervical cancer screening. The split-sample procedure involved direct sampling and spreading with Cervex-Brush®, followed by the collection of the brush tip in a BD SurePathTM vial and BD SurePathTM specimen preparation. SIL detection rates were investigated in two groups: conventional cytology and LBC performed using the split-sample procedure. Split samples were collected from 2,025 women. A SIL was detected in 63 women (3.1%) by conventional cytology [33 cases, low-grade (LSIL); 30 cases, high-grade (HSIL)] and 69 women (3.4%) by BD SurePathTM LBC (37, LSIL; 32, HSIL). The unsatisfactory rate was significantly higher in the conventional cytology than in the BD SurePathTM LBC (p < 0.001). The unsatisfactory rate for BD SurePathTM LBC was 0%. The LBC platform is a standardized LBC system with improved HSIL detection rates and a lower unsatisfactory rate, and is very useful in cervical cancer screening conducted during health check-ups. |
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ISSN: | 0915-8669 2188-5346 |
DOI: | 10.14932/jamt.18-48 |