EXPRESSION OF HLA-DR ANTIGEN ON HEAD AND NECK CARCINOMAS IMMUNOHISTOLOGICAL STUDY

• Published in: Nippon Jibi Inkoka Gakkai Kaiho Vol. 96; no. 1; pp. 88 - 97_1,171
• Main Author: SAMUKAWA, TAKAO
• Format: Journal Article
• Language: English; Japanese
• Published: Japan The Oto-Rhino-Laryngological Society of Japan, Inc 01.01.1993
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell - immunology; Carcinoma, Squamous Cell - pathology; Cytokines - metabolism; Cytokines - pharmacology; Female; head and neck; Head and Neck Neoplasms - immunology; Head and Neck Neoplasms - pathology; HLA-DR antigen; HLA-DR Antigens - analysis; Humans; IFN-γ; Immunohistochemistry; Ki-67; Ki-67 Antigen; Lymphocytes - metabolism; Male; Middle Aged; Neoplasm Proteins - analysis; Nuclear Proteins - analysis; Squamous cell carcinoma; Tumor Cells, Cultured
• ISSN: 0030-6622; 1883-0854
• DOI: 10.3950/jibiinkoka.96.88

We investigated the expression of HLA-DR antigen on 42 squamous cell carcinomas of head and neck using immunohistological methods. Our results indicate significant relationships between HLA-DR antigen expression on carcinomas and lymphocytic infiltration, that is, CD8 positive lymphocytes (CD8/CD3) infiltrated HLA-DR antigen positive carcinomas while CD4 positive cells (CD4/CD3) were found in HLA-DR negative carcinoma. The Ki-67 (a nuclear marker of proliferation) positive rate was lower on HLA-DR positive carcinomas than on negative carcinomas. However, there was no correlation with pathological differentiation, clinical stage or primary lesion. In vitro studies using several cytokines showed that IFN-γ induced expression of HLA-DR antigen and lowered the Ki-67 positive rate on squamous cell carcinomas. It seems that HLA-DR antigen expression on squamous cell carcinomas could be induced by cytokines released from the infiltrating lymphocytes.