SENESCENCE GENE OF HUMAN FIBROBLAST CELLS

Since Dr. Hayflick demonstrated that mammalian cell has a finite replicative life span in 1961, this phenomenon has been termed cellular senescence and various experiments had been carried out to elucidate the mechanisms of senescence. Recent studies using molecular biological techniques have sugges...

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Published inTISSUE CULTURE RESEARCH COMMUNICATIONS Vol. 11; no. 1; pp. 43 - 48
Main Authors Hara, Eiji, Yamaguchi, Tomoko, Nakada, Susumu, Ide, Toshinori, Ode, Kinichiro
Format Journal Article
LanguageJapanese
Published The Japanese Tissue Culture Association 1992
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Summary:Since Dr. Hayflick demonstrated that mammalian cell has a finite replicative life span in 1961, this phenomenon has been termed cellular senescence and various experiments had been carried out to elucidate the mechanisms of senescence. Recent studies using molecular biological techniques have suggested that multiple negative factors regulating cell proliferation are present in senescent cells. We showed that tumor suppressor gene products, retinoblastoma protein (RB) and p53 are directly involved in cellular senescence and exert their negative functions cooperatively using antisense oligomers for these mRNAs. However, these gene products alone are not sufficient to overcome cellular senescence. In this review, we describe and discuss the method to isolate genes which are possibly involved in the process of cellular senescence.
ISSN:0912-3636
1881-3704
DOI:10.11418/jtca1981.11.1_43