Inhibitory effects of Dai-saiko-to (TJ-8) on the cholesterol gallstone formation in hamsters
The effect of Dai-saiko-to (TJ-8) on the cholesterol gallstone formation was investigated in hamsters fed a high glucose diet, as an experimental model for cholesterol gallstone formation. Animals were fed a normal chow or 75% (w/w) glucose diet (lithogenic diet) with or without 1% Dai-saiko-to (w/w...
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| Published in | Tando Vol. 8; no. 1; pp. 9 - 13 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japan Biliary Association
1994
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0914-0077 1883-6879 |
| DOI | 10.11210/tando1987.8.1_9 |
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| Abstract | The effect of Dai-saiko-to (TJ-8) on the cholesterol gallstone formation was investigated in hamsters fed a high glucose diet, as an experimental model for cholesterol gallstone formation. Animals were fed a normal chow or 75% (w/w) glucose diet (lithogenic diet) with or without 1% Dai-saiko-to (w/w) for 4 weeks. The gallstone incidence was 71% in animals fed a high glucose diet, whereas no stones were formed in the other groups. Thus, cholesterol gallstone formation was prevented by the treatment with Dai-saiko-to. The increase in tissue cholesterol (serum, liver, bile)by high glucose feeding was significantly suppressed by Dai-saiko-to. Further, the appearance rate of cholesterol monohydrate crystal in bile or on the surface of gallbladder was significantly reduced in animals treated with Dai-saiko-to. These findings suggest that Dai-saiko-to prevents cholesterol gallstone formation by reducing the bile cholesterol saturation index, and that the reduction in intestinal cholesterol absorption and hepatic cholesterol synthesis may attribute to such an action of Dai-saiko-to. |
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| AbstractList | The effect of Dai-saiko-to (TJ-8) on the cholesterol gallstone formation was investigated in hamsters fed a high glucose diet, as an experimental model for cholesterol gallstone formation. Animals were fed a normal chow or 75% (w/w) glucose diet (lithogenic diet) with or without 1% Dai-saiko-to (w/w) for 4 weeks. The gallstone incidence was 71% in animals fed a high glucose diet, whereas no stones were formed in the other groups. Thus, cholesterol gallstone formation was prevented by the treatment with Dai-saiko-to. The increase in tissue cholesterol (serum, liver, bile)by high glucose feeding was significantly suppressed by Dai-saiko-to. Further, the appearance rate of cholesterol monohydrate crystal in bile or on the surface of gallbladder was significantly reduced in animals treated with Dai-saiko-to. These findings suggest that Dai-saiko-to prevents cholesterol gallstone formation by reducing the bile cholesterol saturation index, and that the reduction in intestinal cholesterol absorption and hepatic cholesterol synthesis may attribute to such an action of Dai-saiko-to. The effect of Dai-saiko-to (TJ-8) on the cholesterol gallstone formation was investigated in hamsters fed a high glucose diet, as an experimental model for cholesterol gallstone formation. Animals were fed a normal chow or 75% (w/w) glucose diet (lithogenic diet) with or without 1% Dai-saiko-to (w/w) for 4 weeks. The gallstone incidence was 71% in animals fed a high glucose diet, whereas no stones were formed in the other groups. Thus, cholesterol gallstone formation was prevented by the treatment with Dai-saiko-to. The increase in tissue cholesterol (serum, liver, bile)by high glucose feeding was significantly suppressed by Dai-saiko-to. Further, the appearance rate of cholesterol monohydrate crystal in bile or on the surface of gallbladder was significantly reduced in animals treated with Dai-saiko-to. These findings suggest that Dai-saiko-to prevents cholesterol gallstone formation by reducing the bile cholesterol saturation index, and that the reduction in intestinal cholesterol absorption and hepatic cholesterol synthesis may attribute to such an action of Dai-saiko-to. 大柴胡湯によるコレステロール胆石形成に対する影響を, コレステロール胆石形成モデルを用いて検討した. 雄性ゴールデンハムスターを, 普通食投与群 (N群: n=12), グルコース食投与群 (L群:n=14), 1%大柴胡湯添加グルコース食投与群 (L+D群:n=12) の3群にわけ4週間飼育した後, 胆石出現率, 胆汁脂質, 血清脂質および肝組織中の脂質の差を検討した. コレステロール胆石の出現率は, L群において71%と高率であったが, NおよびL+D群においては胆石形成を認めなかった. 胆汁中の胆石形成指数は, N群0.44±0.28, L群0.85±0.19, L+D群0.43±0.24 と大柴胡湯投与により有意に低下していた. 一方, 血清脂質は, コレステロール, 中性脂肪ともにL群においてN群, L+D群に比し有意に上昇したが, N群, L+D群間に有意の差は認めなかった. 肝組織中の脂質はN群に比べL+D群において遊離コンステロールの低下, コレステロールエステルの上昇, L群においては逆の変化を認めた. 以上より, 大柴胡湯は, 腸管でのコレスデロール吸収抑制, 肝でのコレステロール合成抑制および胆汁酸への異化亢進により, 胆汁中コレステロール飽和度を低下させ, 胆石形成に抑制的に作用することが示唆された. |
| Author | MIURA, Hiroyuki SASAKI, Masatoshi OCHI, Hidenori AIHARA, Naoki HATSUSHIKA, Sumie TAZUMA, Susumu YAMASHITA, Yoshifumi HORIKAWA, Kazuhiko HIRANO, Tadamichi OHYA, Toshihide TERAMEN, Kazushi KAJIYAMA, Goro |
| Author_FL | 相原 直樹 梶山 梧朗 山下 喜史 佐々木 雅敏 堀川 和彦 越智 秀典 寺面 和史 三浦 弘之 田妻 進 初鹿 寿美恵 平野 巨通 大屋 敏秀 |
| Author_FL_xml | – sequence: 1 fullname: 相原 直樹 – sequence: 2 fullname: 田妻 進 – sequence: 3 fullname: 大屋 敏秀 – sequence: 4 fullname: 初鹿 寿美恵 – sequence: 5 fullname: 山下 喜史 – sequence: 6 fullname: 堀川 和彦 – sequence: 7 fullname: 越智 秀典 – sequence: 8 fullname: 寺面 和史 – sequence: 9 fullname: 平野 巨通 – sequence: 10 fullname: 三浦 弘之 – sequence: 11 fullname: 佐々木 雅敏 – sequence: 12 fullname: 梶山 梧朗 |
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| References | 5) Ebihara K, Kiriyama S: Prevention of cholesterol gallstones by a water-soluble dietary fiber, konjac mannan, in mice. Nutrition Reports International 32: 223-229, 1985 4)斉藤 隆: 漢方方剤大柴胡湯及び柴胡中の Saponin 成分の実験的高脂血症に対する効果. 東京医大誌 40: 517-529, 1982 6) Miyada T, Ogino H, Okuda H: Preventive effect of Dai-saiko-to (Da-Chai-Hu-Tang) extract on gallstone formatiom in mice fed a lithogenic diet. 和漢医薬学会誌 4: 73-75, 1987 3)日野文明: キャピラリーガスクロマトグラフィーによる胆汁脂質同時測定法の研究. 日消病会誌 85: 73-80, 1988 7) Tao S, Tazurna S, Kajiyama G: Fatty acid composition of lecithin is a key factor in bile metasta bility in supersaturated model bile systems. Biochern Biophys Acta 1167: 142-146, 1993 9)酒 堅: 全幹迷走神経切離術後の胆石形成抑制に関する実験的研究. 和漢医薬学会誌 7: 132-137, 1990 10)大南宏治, 松岡栄子, 奥田拓道ほか: 脂質の腸間吸収に及ぼす大柴胡湯の作用. 薬理と治療 13: 5097-5099, 1985 12) Miyada T, Ogino H, Okuda H: Effect of Daisaikoto extract on the hiliary constituents in mice and rats. Agric Biol Chem 52: 2065-2069, 1988 11) Yamamoto M, Kumagai A, Yamamura Y: Plasma Lipid-lowering Action of Ginseng Saponin s and Mechanism of the Action. Amer J Chinese Med 11: 84-87, 1983 2)小出和伸, 平田康彦, 大谷博正ほか: グルコース食投与ハムスターにおける胆汁酸および脂質代謝. 胆道 2: 437-443, 1988 8) Ohya T, Schwarzendrube J, B usch N, et al: I solation of a Human Biliary Glycoprotein Inhibito r of Cholesterol Crystallization. Gastroenterology 104: 527-538, 1993 1) Tazuma S, Sasaki H, Mizuno S, et al: Effect of Ursodeoxycholic Acid Administration on Nucleation time in Human Gallbladder Bile. Gastro e nterology 97: 173-178, 1989 |
| References_xml | – reference: 5) Ebihara K, Kiriyama S: Prevention of cholesterol gallstones by a water-soluble dietary fiber, konjac mannan, in mice. Nutrition Reports International 32: 223-229, 1985 – reference: 3)日野文明: キャピラリーガスクロマトグラフィーによる胆汁脂質同時測定法の研究. 日消病会誌 85: 73-80, 1988 – reference: 1) Tazuma S, Sasaki H, Mizuno S, et al: Effect of Ursodeoxycholic Acid Administration on Nucleation time in Human Gallbladder Bile. Gastro e nterology 97: 173-178, 1989 – reference: 6) Miyada T, Ogino H, Okuda H: Preventive effect of Dai-saiko-to (Da-Chai-Hu-Tang) extract on gallstone formatiom in mice fed a lithogenic diet. 和漢医薬学会誌 4: 73-75, 1987 – reference: 4)斉藤 隆: 漢方方剤大柴胡湯及び柴胡中の Saponin 成分の実験的高脂血症に対する効果. 東京医大誌 40: 517-529, 1982 – reference: 7) Tao S, Tazurna S, Kajiyama G: Fatty acid composition of lecithin is a key factor in bile metasta bility in supersaturated model bile systems. Biochern Biophys Acta 1167: 142-146, 1993 – reference: 11) Yamamoto M, Kumagai A, Yamamura Y: Plasma Lipid-lowering Action of Ginseng Saponin s and Mechanism of the Action. Amer J Chinese Med 11: 84-87, 1983 – reference: 8) Ohya T, Schwarzendrube J, B usch N, et al: I solation of a Human Biliary Glycoprotein Inhibito r of Cholesterol Crystallization. Gastroenterology 104: 527-538, 1993 – reference: 12) Miyada T, Ogino H, Okuda H: Effect of Daisaikoto extract on the hiliary constituents in mice and rats. Agric Biol Chem 52: 2065-2069, 1988 – reference: 9)酒 堅: 全幹迷走神経切離術後の胆石形成抑制に関する実験的研究. 和漢医薬学会誌 7: 132-137, 1990 – reference: 2)小出和伸, 平田康彦, 大谷博正ほか: グルコース食投与ハムスターにおける胆汁酸および脂質代謝. 胆道 2: 437-443, 1988 – reference: 10)大南宏治, 松岡栄子, 奥田拓道ほか: 脂質の腸間吸収に及ぼす大柴胡湯の作用. 薬理と治療 13: 5097-5099, 1985 |
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| SubjectTerms | コンステロール胆石 大柴胡湯 胆汁酸 胆石形成指数 |
| Title | Inhibitory effects of Dai-saiko-to (TJ-8) on the cholesterol gallstone formation in hamsters |
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