Inhibitory effects of Dai-saiko-to (TJ-8) on the cholesterol gallstone formation in hamsters

• Published in: Tando Vol. 8; no. 1; pp. 9 - 13
• Main Authors: OHYA, Toshihide, SASAKI, Masatoshi, AIHARA, Naoki, OCHI, Hidenori, HORIKAWA, Kazuhiko, HIRANO, Tadamichi, YAMASHITA, Yoshifumi, TERAMEN, Kazushi, HATSUSHIKA, Sumie, TAZUMA, Susumu, MIURA, Hiroyuki, KAJIYAMA, Goro
• Format: Journal Article
• Language: Japanese
• Published: Japan Biliary Association 1994
• Subjects: コンステロール胆石; 大柴胡湯; 胆汁酸; 胆石形成指数
• ISSN: 0914-0077; 1883-6879
• DOI: 10.11210/tando1987.8.1_9

The effect of Dai-saiko-to (TJ-8) on the cholesterol gallstone formation was investigated in hamsters fed a high glucose diet, as an experimental model for cholesterol gallstone formation. Animals were fed a normal chow or 75% (w/w) glucose diet (lithogenic diet) with or without 1% Dai-saiko-to (w/w) for 4 weeks. The gallstone incidence was 71% in animals fed a high glucose diet, whereas no stones were formed in the other groups. Thus, cholesterol gallstone formation was prevented by the treatment with Dai-saiko-to. The increase in tissue cholesterol (serum, liver, bile)by high glucose feeding was significantly suppressed by Dai-saiko-to. Further, the appearance rate of cholesterol monohydrate crystal in bile or on the surface of gallbladder was significantly reduced in animals treated with Dai-saiko-to. These findings suggest that Dai-saiko-to prevents cholesterol gallstone formation by reducing the bile cholesterol saturation index, and that the reduction in intestinal cholesterol absorption and hepatic cholesterol synthesis may attribute to such an action of Dai-saiko-to.