CHEMOTHERAPY OF BILIARY TRACT INFECTIONS (XXV), COMPARATIVE CROSSOVER STUDY OF THE RELATION BETWEEN DRUG EXCRETION IN BILE AND BACTERIAL COUNT

• Published in: CHEMOTHERAPY Vol. 32; no. 7; pp. 458 - 470
• Main Author: TANIMURA, HIROSHI
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 25.07.1984
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.32.458

Efficacy of drugs in the field of biliary tract infections has been compared by the drug concentration in bile since 1975. We performed comparative crossover study of ofloxacin and PMPC by determination of bacterial count in bile and the following results were obtained. 1) Fifteen patients with T-tube were randomly divided into two groups. Bacteria were isolated in bile from these patients. In group A, four tablets (200mg) of ofloxacin were administered three times daily for 4 days. Placebo tablets was administered on Day 5, and from Day 6 three tablets (150mg) of PMPC and one placebo tablet were administered three times daily for 4 days. In group B, seven patients were given ofloxacin and PMPC in the reversed order. Bile samples for determination of bacterial count were diluted 100 times by saline and stored at 4°C in an anaerobic vial and identification of bacteria and MIC were determined after storage. 2) In group A, one strain of E. coli and two strains of Acinetobacter were eradicated during 4 days treatment with ofloxacin. Although two strains of E. coli, two strains of K. oxytoca and two strains