Development of 19F-NMR chemical shift detection of DNA B-Z equilibrium using 19F-NMR

Various DNA conformational changes are in correlation with biological events. In particular, DNA B-Z equilibrium showed a high correlation with translation and transcription. In this study, we developed a DNA probe containing 5-trifluoromethylcytidine or 5-trifluoromethylthymidine to detect DNA B-Z...

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Published inOrganic & biomolecular chemistry Vol. 15; no. 24; pp. 5109 - 5111
Main Authors Nakamura, S, Yang, H, Hirata, C, Kersaudy, F, Fujimoto, K
Format Journal Article
LanguageEnglish
Published 28.06.2017
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Summary:Various DNA conformational changes are in correlation with biological events. In particular, DNA B-Z equilibrium showed a high correlation with translation and transcription. In this study, we developed a DNA probe containing 5-trifluoromethylcytidine or 5-trifluoromethylthymidine to detect DNA B-Z equilibrium using 19F-NMR. Its probe enabled the quantitative detection of B-, Z-, and ss-DNA based on 19F-NMR chemical shift change.
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ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob00706j