Influence of Hematocrit Value on Removal Effeciency of Beta-2-microglobulin using High Flux Membrene Dialyzer

• Published in: Jinko Zoki Vol. 19; no. 2; pp. 703 - 706
• Main Authors: SAKASHITA, K., TUTUI, T., YAMOTO, N., YAMAZAKI, T., ITO, A., MASUKO, K., WATANABE, Y.
• Format: Journal Article
• Language: Japanese
• Published: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS 15.04.1990
• Subjects: beta-2-microglobulin; dialyzer clearance; hematocrit; removal amount; removal rate
• ISSN: 0300-0818; 1883-6097
• DOI: 10.11392/jsao1972.19.703

We studied whether or not the hematocrit (Ht) values in 25 hemodialysis patients using high flux membrane dialyzers influenced on removal effeciency (removal rate, removal amount and clearance) of beta-2-microglobulin (B2-m). The removal rates were 30.1±11.9% at 24.0±3.1% of Ht values and 30.4±9.1% at 29.0±3.1%. In spite of the 11.5 points increases of Ht (from 25.2±3.8% to 36.7±5.6%), there were no changes in the removal rates (from 34.7±18.4% to 34.5±15.4%) . There was significant correlation between Ht and removal rates in only two cases among eleven cases. In two cases, one was positive, one, negative correlation coefficent. There was no constant trend in the relation of Ht and the removal rates. There was significant correlation between the serum B2-m concentration and the removal amounts, but no correlation between Ht and the removal amounts. The dialyzer clearances calculated from dialysate were 24.2±6.5ml/min on FB-150U. 18.7±2.5ml/min on FB-110U, 8.8±1.6ml/min on AM-UP-21 and 8.1±0.8ml/min on AM-UP-15. but the correlation between Ht and the dialyzer clearances was not significantly on all dialyzers. We concluded that Ht did not influenced the removal effeciency of B2-m using high flux membrane dialyzer.