Antitumor effect of ethylenevinyl alcohol copolymer matrices containing anticancer agents by topical administration

• Published in: Jinko Zoki Vol. 14; no. 2; pp. 826 - 829
• Main Authors: MIYAZAKI, S., TAKEUCHI, S., HOU, Wei-Min, HASHIGUCHI, N., YOKOUCHI, C., TAKADA, M., HOSOKAWA, M., KOGA, Y., KOBAYASHI, H.
• Format: Journal Article
• Language: Japanese
• Published: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS 15.04.1985
• Subjects: anticancer agent; controlled release; drug delivery; ethylene-vinyl alcohol; sustained release

Antitumor activity of ethylene-vinyl alcohol (EVA1) copolymer matrices containing 5-FU or adriamycin was evaluated against Ehrlich ascites carcinoma in mice. A prolongation of the life-span of the animals following intraperitoneal implantation of therapeutic matrices was noted. Matrices composed of...