Antitumor effect of ethylenevinyl alcohol copolymer matrices containing anticancer agents by topical administration

Antitumor activity of ethylene-vinyl alcohol (EVA1) copolymer matrices containing 5-FU or adriamycin was evaluated against Ehrlich ascites carcinoma in mice. A prolongation of the life-span of the animals following intraperitoneal implantation of therapeutic matrices was noted. Matrices composed of...

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Bibliographic Details
Published inJinko Zoki Vol. 14; no. 2; pp. 826 - 829
Main Authors MIYAZAKI, S., TAKEUCHI, S., HOU, Wei-Min, HASHIGUCHI, N., YOKOUCHI, C., TAKADA, M., HOSOKAWA, M., KOGA, Y., KOBAYASHI, H.
Format Journal Article
LanguageJapanese
Published JAPANESE SOCIETY FOR ARTIFICIAL ORGANS 15.04.1985
Subjects
anticancer agent
controlled release
drug delivery
ethylene-vinyl alcohol
sustained release
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Summary:Antitumor activity of ethylene-vinyl alcohol (EVA1) copolymer matrices containing 5-FU or adriamycin was evaluated against Ehrlich ascites carcinoma in mice. A prolongation of the life-span of the animals following intraperitoneal implantation of therapeutic matrices was noted. Matrices composed of EVA1 copolymer could be useful vehicles for topical administration of anticancer agents.
ISSN:0300-0818
1883-6097
DOI:10.11392/jsao1972.14.826