Evaluation of Porto-systemic Shunt by Transrectal Portal Scintigraphy with 123I-IMP

• Published in: RADIOISOTOPES Vol. 41; no. 12; pp. 632 - 637
• Main Authors: YANAGISAWA, Toru, OBARA, Toya, ONO, Megumi, KUMAGAI, Yoshiki, KATO, Kunihiko, TAKAHASHI, Tsuneo
• Format: Journal Article
• Language: Japanese
• Published: Japan Radioisotope Association 15.12.1992
• Subjects: diffuse liver disease; iodine-123-isopropyl iodoamphetamine; porto-systemic shunt; transrectal portal scintigraphy
• ISSN: 0033-8303; 1884-4111
• DOI: 10.3769/radioisotopes.41.12_632

Porto-systemic shunt was evaluated by portal scintigraphy with rectal administration of 123I-IMP in 18 patients with diffuse liver diseases. A dose of 123I-IMP (111 MBq) was administered to the upper rectum through a catheter. Images of the chest and abdomen were obtained with a large field of scintillation camera interfaced with a computer up to 60 min. In all patients, the liver and /or lung images were visualized for 5-10 min and became clear with time. Time-activity curves on the liver and /or lungs rose steadily after123I-IMP administration, The porto-systemic shunt index was obtained by dividing counts for lungs by those for liver and lungs. These values were higher in liver cirrhosis, especially in the decompensated stage and correlated siginificantly with ICGR15 on the liver function test. In conclusion, transrectal portal scintigraphy with 123I-IMP is useful for the noninvasive and quantitative evaluation of porto-systemic shunt in patients with liver diseases.