A Tumor-specific Localizing Agent for Radioisotope Image (II) The Synthesis of 6-Iodopurine-131I and Its Distribution in Tumor Bearing Mice

6-Iodopurine-131 I was synthesized by the exchange reaction of 6-IP with Na131 I. Specific activity of synthesized 6-iodopurine was 0.42 mCi/mg (0.52 mCi/ml), and the yield of 6-iodo purine-131 I was 52%. The autoradiol ysis was not detected in 25 days. Studies of distribution of 6-iodopurine131 I i...

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Published inRADIOISOTOPES Vol. 18; no. 10; pp. 432 - 436
Main Authors MAEDA, Tatsuo, KOMAKI, Senichiro, KAMOI, Itsuma, KOJIMA, Masaharu, NAGAO, Koichiro
Format Journal Article
LanguageJapanese
Published Japan Radioisotope Association 15.10.1969
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Summary:6-Iodopurine-131 I was synthesized by the exchange reaction of 6-IP with Na131 I. Specific activity of synthesized 6-iodopurine was 0.42 mCi/mg (0.52 mCi/ml), and the yield of 6-iodo purine-131 I was 52%. The autoradiol ysis was not detected in 25 days. Studies of distribution of 6-iodopurine131 I in mice and scintiphotography indicated that the intraperitoneally injected 6-iodopurine-131 I-was incorporated into the stomach and tumor. Considerably large amount of 6-iodopurine-131 I was found in the implanted tumor tissue 2 hours after intraperitoneal injection. Incorporation of 6-iodopurine-131 I in tumor nucleus was showed by the microautoradiography.
ISSN:0033-8303
1884-4111
DOI:10.3769/radioisotopes.18.10_432