STUDY ON FOSFOMYCIN-SODIUM-SALT

Basic and clinical studies were conducted on FOM-Na. The MIC was low especially against Proteus spp. High blood concentrations were obtained following intravenous one shot administration, intravenous drip-infusion, and intrathorax administration, being considered effective against most of the organi...

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Published inCHEMOTHERAPY Vol. 23; no. 11; pp. 3316 - 3326
Main Authors SHIMIZU, TATSUNORI, TAKAGI, YASUO, SAITO, NAGANORI, YOKOYAMA, MICHIO, KOBAYASHI, TAKESHI, HIRAI, HIDEYUKI, ANZAI, TSUTOMU, SAITO, NOBUTERU, ONUMA, HIROAKI, NITTA, HIDEAKI
Format Journal Article
LanguageJapanese
Published Japanese Society of Chemotherapy 1975
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Abstract Basic and clinical studies were conducted on FOM-Na. The MIC was low especially against Proteus spp. High blood concentrations were obtained following intravenous one shot administration, intravenous drip-infusion, and intrathorax administration, being considered effective against most of the organisms tested for MIC. FOM was excreted in the urine at high concentration, the excretion rate was good, and more than 90% of the given dose were excreted within 12 hours after administration. The excretion route of FOM is considered through the kidney. The active substance in the blood, urine, saliva, and pleural effusion was inferred to be FOM according to the spot obtained in the bioautogram of TLC. The clinical result showed both effective and poor cases, though the number of cases was small. No side effects.
AbstractList Basic and clinical studies were conducted on FOM-Na. The MIC was low especially against Proteus spp. High blood concentrations were obtained following intravenous one shot administration, intravenous drip-infusion, and intrathorax administration, being considered effective against most of the organisms tested for MIC. FOM was excreted in the urine at high concentration, the excretion rate was good, and more than 90% of the given dose were excreted within 12 hours after administration. The excretion route of FOM is considered through the kidney. The active substance in the blood, urine, saliva, and pleural effusion was inferred to be FOM according to the spot obtained in the bioautogram of TLC. The clinical result showed both effective and poor cases, though the number of cases was small. No side effects.
Author SHIMIZU, TATSUNORI
SAITO, NAGANORI
YOKOYAMA, MICHIO
KOBAYASHI, TAKESHI
NITTA, HIDEAKI
SAITO, NOBUTERU
TAKAGI, YASUO
ANZAI, TSUTOMU
HIRAI, HIDEYUKI
ONUMA, HIROAKI
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  organization: Department of Third Internal Medicine, Sapporo Medical College
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  fullname: TAKAGI, YASUO
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  fullname: SAITO, NAGANORI
  organization: Department of Third Internal Medicine, Sapporo Medical College
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  fullname: YOKOYAMA, MICHIO
  organization: Department of Third Internal Medicine, Sapporo Medical College
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  fullname: KOBAYASHI, TAKESHI
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  fullname: HIRAI, HIDEYUKI
  organization: Department of Third Internal Medicine, Sapporo Medical College
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  fullname: ANZAI, TSUTOMU
  organization: Department of Third Internal Medicine, Sapporo Medical College
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  fullname: SAITO, NOBUTERU
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  fullname: ONUMA, HIROAKI
  organization: Department of Third Internal Medicine, Sapporo Medical College
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  fullname: NITTA, HIDEAKI
  organization: Department of Third Internal Medicine, Sapporo Medical College
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References 4) ZIMMERMAN, S. B..; E. 0. STAPLEY, H. WALLICK & R. BALDWIN : Phosphonomycin. IV. Susceptibility testing method and survey. Antimicr. Agents & Chemoth.-1969 : 303 309, 1970
2) MILLER, A. K., B. M. FROST, M. E. VALIANT, H. KROPP & D. HENDLIN : Phosphonomycin. V. Evaluation in mice. Antimicr. Agents & Chemoth.-1969 : 310-315, 1970
3) STAPLEY, E. O. ; D. HENDLIN, J.M. MATA, M. JACKSON, H. WALLIK, S. HERNANDEZ, S. MOCHALES, S. A. CURRIE & R. M. MILLER : Phosphonomycin. I. Discovery and in vitro biological characterization. Antimicr. Agents & Chemoth.-1969 : 284-290, 1970
1) HENDLIN, D.; B. M. FROST, E. THIELE, H. KROPP, M. E. VAUNT, B. PELAK, B. WEISS BERGER, C. CORIN & A. K. MILLER : Phosphonomycin. III. Evaluation in vitro. Antimicr. Agents & Chemoth.-1969 : 297-302,302, 1970
6) 清水辰典, 高木康夫, 斎藤永憲, 横山道夫, 小林武, 平井英幸, 新田秀昭, 斉藤宣照, 大沼広明, 常松和則 : Fosfomycin-Caに関する研究. Chemotherapy23 : 1700-1708, 1975
8) 清水辰典 : 未発表
7) FOLTZ, E. L & H. WALHCK : Pharmacodynamics of phosphonomycin after intravenous administration in man. Antimicr. Agents & Chemoth.-1969 : 316-321, 1970
5) FOLTZ, E. L.; H. WALLICK & C. ROSENBLUM : Pharmacodynamics of phosphonomycin after oral administration in man. Antimicr. Agents & Chemoth.-1969 : 322-326, 1970
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